| 王永祥 曹金凤 蒋留琴 鲁彦斌 李鹤云 杜建龙 薛荣亮.全麻复合硬膜外麻醉对胃癌根治术围术期纤溶功能的影响[J].现代生物医学进展英文版,2016,16(23):4512-4515. |
| 全麻复合硬膜外麻醉对胃癌根治术围术期纤溶功能的影响 |
| Effects of General Anesthesia Combined with Epidural Anesthesia onPerioperative Fibrinolysis for Patients with Gastric Cancer |
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| DOI： |
| 中文关键词: 全身麻醉 连续硬膜外麻醉 胃癌根治 纤溶功能 |
| 英文关键词: Anesthesia Epidural anesthesia Gastric cancer Fibrinolysis |
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| 中文摘要: |
| 目的：探讨全身麻醉复合连续硬膜外麻醉对胃癌根治患者围术期纤溶功能的影响。方法：选择2013 年4 月到2015 年6 月
在我院进行胃癌根治手术的患者80 例，根据随机数字表法分为治疗组40 例与对照组40 例，对照组给予全身麻醉，治疗组给予
全身麻醉复合连续硬膜外麻醉，对两组患者血流动力学指标，纤溶功能以及下肢深静脉血栓发生情况进行观察与比较。结果：所
有患者都完成手术，诱导后患者的MAP 与HR值与诱导前比较差异都有统计学意义(P<0.05)，不过组间对比无显著性差异(P>0.
05)，术毕MAP 与HR值在组内与组间比较均无显著性差异(P>0.05)。治疗组诱导后5 min与术毕的血清D-二聚体和纤维蛋白原
值都明显低于对照组，且与诱导前对比差异也有统计学意义(P<0.05)。治疗组术后下肢深静脉血栓发生率明显低于对照组(P<0.
05)。结论：全身麻醉复合连续硬膜外麻醉能改善胃癌根治患者围术期纤溶功能，从而减轻患者高凝状态，安全性好，有效预防下肢
深静脉血栓的形成。 |
| 英文摘要: |
| Objective:To investigate the effects of general anesthesia combined with epidural anesthesia on perioperative fibrinolysis
function for patient with gastric cancer.Methods:From April 2013 to June 2015 in our hospital, 80 patients with gastric cancer who
needed radical surgery were selected and equally divided into treatment group and control group, 40 patients each group. The patients in
control group were given general anesthesia, and the patients in treatment group were given general anesthesia combined with epidural
anesthesia. Then the indexes of haemodynamics, fibrinolytic function and the incidence of deep vein thrombosis of two groups were observed
and compared.Results:All patients were completed the surgery, and the MAP and HR values in the patient after induction were
statistically significant differences compared with before induction (P <0.05), but had no significant difference in comparison between the
two groups (P>0.05), and the MAP and HR values after surgery were showed no significant difference in comparison within the group
and between the two groups (P>0.05). The serumD- dimer and fibrinogen values in the times of induction 5 min and after surgery in the
treatment group were significantly lower than that of the control group, and the differences were statistically significant compared with
before induction (P<0.05). The incidence of deep vein thrombosis was 5.0%in the treatment group, and 17.5 %in the control group, and
it was significantly lower in the treatment group than that of the control group (P<0.05).Conclusion:General anesthesia combined with
epidural anesthesia in operative treatment of gastric cancer patients can improve perioperative fibrinolysis, thus reduce patients' hypercoagulable
state, has good security and can effectively prevent the formation of deep vein thrombosis. |
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