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目的：探讨绝经后女性血清25羟维生素D[25(OH)D]与高血压的相关性。方法：选取456 例绝经后女性为研究对象，按照是否存在高血压分为高血压组(n=102 例)和非高血压组(n=354 例)，测定所有患者的血清25(OH)D 水平；血清25(OH)D 水平分为四组：即25(OH) D≥ 30 ng/mL 组(n=50 例)、21～29 ng/mL 组(n=110 例)、10～20 ng/mL 组(n=240 例)、25(OH) D＜10 ng/mL 组(n=56 例)；比较各组相关指标的差异。并利用Logistic 回归方程分析血清25(OH)D 与高血压发生的关系。结果：高血压组与非高血压组在体质指数(BMI)、收缩压(SBP)、舒张压(SDP)、雌激素、高敏C 反应蛋白(hs-CRP)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)方面存在统计学差异(P＜0.05)；高血压组血清25(OH)D[14.56± 3.21(ng/ml)]低于非高血压组[19.89± 4.75(ng/ml)] (t=10.649，P＜0.001)；在血清25(OH) D＜10 ng/mL 组中，SBP 和SDP 值、高血压发生率均高于25(OH) D≥ 30 ng/mL 组、21～29 ng/mL 组(n=110 例)、10～20 ng/mL 组(P＜0.05)；血清25(OH)D 水平与绝经后女性发生高血压呈现负相关(P＜0.05)。在血清25 (OH)D不同分组中，从25(OH) D≥ 30 ng/mL组到25(OH) D＜10 ng/mL组发生高血压的风险值依次增加。结论：血清25(OH)D 水平与绝经后高血压的发生密切相关，随着血清25(OH)D 水平的逐渐降低，高血压发生的风险亦逐渐增大。

英文摘要:

Objective:To explore the relationship of 25 hydroxy serum vitaminD [25 (OH) 2 D] with high blood pressure of the postmenopausal women.Methods:We selected 456 cases of postmenopausal women in our hospital as the research objects. They were divided into two groups according to whether they had hypertension: hypertension group (n=102) and no hypertension group (n=354). All patients had their serum25 (OH) D levels detected. And then they were divided into four groups: 25- (OH) D > 30 ng/L group (n=50), 21~29 ng/L group (n=110), 10~20 ng/L group (n=240), 25 (OH) D < 10 ng/L group (n=56). Compare the difference of related indicators between the groups, and analyze the relationship of serum25 (OH) 2 D with hypertension by using logistic regression equation.Results:There were statistically significant differences between hypertension group and no hypertension group in BMI, systolic blood pressure (SBP), diastolic blood pressure (SDP), estrogen, high-sensitivity C-reactive protein (hs-CRP), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and fasting plasma glucose (FPG) (P<0.05). Hypertension group had lower levels of serum 25 (OH) D3 [14.56 ± 3.21 (ng/mL)] than the no hypertension group [19.89± 4.75 (ng/mL)] (t=10.649, P<0.001). In the serum 25(OH)D < 10 ng/L group, SBP and SDP value and the incidence of hypertension were higher than in the 25 (OH)D > 30 ng/L group, 21~29 ng/L group and 10~20 ng/L group (P<0.05). Serum 25(OH)D levels presented negative correlation with hypertension of postmenopausal women (P<0.05). In serum 25 (OH) D groups, from 25(OH)D > 30 ng/L to 25(OH)D < 10 ng/L group, the risk of high blood pressure increased in turn.Conclusion:The serum25 (OH) D level was closely related to the occurrence of postmenopausal hypertension. Along with the serum25 (OH) D level gradually reduced, the risk of hypertension occurrence gradually increased.

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