| 范维 杨桂 徐智高 徐婷 唐诗慧 喻明霞.AECOPD患者血清PCT, UA, WBC和Glu 的水平变化及其临床意义[J].现代生物医学进展英文版,2016,16(23):4443-4446. |
| AECOPD患者血清PCT, UA, WBC和Glu 的水平变化及其临床意义 |
| The Changes and Clinical Implications of SerumPCT, UA, WBC and GluLevels in AECOPD |
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| DOI： |
| 中文关键词: 慢性阻塞性肺疾病急性加重 降钙素原 尿酸 空腹血糖 白细胞计数 |
| 英文关键词: Acute Exacerbation Chronic obstructive pulmonary disease Procalcitonin Uric acid Fast blood glucose white blood
cell count |
| 基金项目:国家自然科学基金面上项目（81472033）；武汉市科技攻关项目（2014060101010045）；
湖北省卫生计生科研基金项目（WJ2015Q021）；湖北省自然科学基金项目（2013CFB233；2013CFB235） |
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| 中文摘要: |
| 目的：探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者血清降钙素原(PCT)、尿酸(UA)、白细胞计数(WBC)、空腹血糖(Glu)
的变化及其在AECOPD 中的临床意义。方法：收集2014年9 月至2015 年9 月期间就诊于我院的AECOPD患者45 例、COPD 稳
定期患者30 例及健康受试者45 例。分别采用荧光法、血液分析仪和生化分析仪测定受试者血清PCT、WBC、UA和Glu 水平，并
进行统计学分析。结果：与COPD 稳定期及健康对照组相比，AECOPD 患者PCT (0.23± 0.23 vs. 0.13± 0.16，0.01± 0.03)、UA
(410.54 ± 81.35 vs. 324.44 ± 57.71，264.32 ± 52.23)、WBC (8.88 ± 4.28 vs. 7.65 ± 1.66，6.59 ± 1.14)、Glu (6.22 ± 1.14 vs. 5.62 ±
0.98，4.35± 0.62)水平均明显升高(P＜0.05)。PCT、UA、WBC、Glu诊断AECOPD 的ROC 曲线下面积分别为0.834、0.939、0.643、
0.933，AUCGlu＞AUCPCT＞AUCWBC 有统计学意义(P＜0.05)，AUCUA＞AUCGlu 无统计学意义(P＞0.05)。结论：PCT、UA、
WBC、Glu 水平对AECOPD患者具有一定的诊断意义，以UA和Glu 的诊断价值更高。 |
| 英文摘要: |
| Objective:To investigate the changes and clinical implications of serum PCT, UA, WBC and Glu levels in AECOPD.Methods:45 cases of AECOPD patients, 30 cases of COPD stable patients and 45 cases of healthy examination people were included in
this study from September 2014 to September 2015. Immunofluorescence, blood analyzer and biochemical analyzer were used to detect
the serum PCT, WBC, UA, Glu in participants.Results:Compared with patients with COPD stable and control group, patients with AECOPD
had statistically high level of PCT (0.23± 0.23 vs. 0.13± 0.16 0.01± 0.03), UA (410.54± 81.35 vs. 324.44± 57.71 264.32±
52.23), WBC (8.88± 4.28 vs. 7.65± 1.66 6.59± 1.14), Glu (6.22± 1.14 vs. 5.62± 0.98 4.35± 0.62) (P＜0.05). The AUC of ROC curve
of PCT, UA, WBC, Glu were 0.834, 0.939, 0.643, 0.933 respectively in the diagnosis of AECOPD, and the difference were statistically
significant between AUCGlu＞AUCPCT＞AUCWBC (P＜0.05), but not in AUCUA＞AUCGlu (P＞0.05).Conclusion:PCT, UA,
WBC, Glu could be used to diagnose AECOPD, and UA, Glu seem to be more useful, which provided new references for the diagnosis,
treatment and prognostic evaluation of AECOPD. |
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