| 靳瑾 苟静 李晓岚 薛以贵 张春雪.2 型糖尿病患者胰高血糖素及胰岛素水平检测及临床意义[J].现代生物医学进展英文版,2016,16(22):4381-4383. |
| 2 型糖尿病患者胰高血糖素及胰岛素水平检测及临床意义 |
| The Clinical Significance and Detection of Glucagon and Insulin Levels inType 2 Diabetes |
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| DOI： |
| 中文关键词: 2 型糖尿病 胰高血糖素 胰岛素 |
| 英文关键词: Type 2 diabetes Glucagon Insulin |
| 基金项目:新疆医科大学科研创新基金项目（XJC2012133） |
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| 中文摘要: |
| 目的：探讨2 型糖尿病患者经标准馒头餐试验后胰高血糖素、胰岛素水平变化及其临床意义。方法：选取我院2014 年3 月
至2015 年3 月收治的80 例2 型糖尿病患者为试验组，均接受标准馒头餐试验，对其餐前及餐后0.5 h、1 h、2 h胰高血糖素及胰
岛素水平进行检测，并与同期80 例血糖无异常的健康对照组作比较。结果：健康对照组餐前及餐后胰高血糖素水平无明显变化
（P＞0.05），而试验组餐前胰高血糖素水平明显高于健康对照组（P＜0.05），且餐后明显升高，在餐后1 h 达到峰值，餐后0.5 h、1h、
2 h 均明显高于健康对照组（P＜0.01）。健康对照组餐后胰岛素水平明显升高，在餐后1 h 达到峰值后开始降低，较餐前略高，但差
异平无统计学意义（P＞0.05）；试验组餐前胰岛素水平明显低于健康对照组（P<0.05），且餐后水平升高幅度缓慢，餐后0.5 h、1 h、2
h 均明显低于健康对照组（P＜0.05）；实验组胰岛素抵抗指数(HOMA-IR)明显高于健康对照组，经Pearson 相关分析，试验组餐后
0.5 h、1 h、2 h胰高血糖素水平与HOMA-IR 均呈明显的正相关（r=0.273、0.335、0.368，P＜0.05）。结论：2型糖尿病患者血糖高表达
与胰高血糖素、胰岛素水平密切相关，胰高血糖素可拮抗胰岛素，及时检测二者的水平对临床准确评估病情具有重要的意义。 |
| 英文摘要: |
| Objective:To explore the changes of glucagon, and insulin levels after standard test meal bread in type 2 diabetic patients
and its clinical significance.Methods:80 cases of patients with type 2 diabetes who were treated in our hospital from March 2014
to March 2015 were selceted as the experimental group,they wer recieved underwent a standard test meal bread, the glucagon and insulin
levels was detected fasting and postprandial 0.5 h, 1 h, 2 h detecting, and compared with 80 cases without abnormal glucose control
group.Results:The glucagon levels of control group have no obvious predinner and postprandial (P>0.05), while the experimental group
pre-dinner glucagon level was significantly higher than control group (P<0.05), and it significantly increased after meal, which peaked at
1h after the meal, which were significantly higher than that of healthy controls after test meal 0.5 h, 1 h, 2 h (P<0.01). The level of postprandial
insulin of control group rised obviously, and peaked after a meal of 1 h began to reduce, which was slightly higher than before
meal, but the difference was no statistical significance (P>0.05); The level of pre-dinner insulin of experimental group was significantly
lower than that of control group (P<0.05), and the level rised slowly after meal, which they were significantly lower than that of healthy
controls after 0.5 h, 1 h, 2 h(P<0.05). The insulin resistance index(HOMA-IR)in the experimental group was significantly higher than that
of the healthy control group, Pearson correlation analysis showed, the experimental group postprandial 0.5 h, 1 h, 2 h of glucagon were
positively correlated with HOMA-IR (r=0.273, 0.335, 0.368, P<0.05).Conclusion:The high blood sugar levels of type 2 diabetes is closely
related to glucagon, glucagon can antagonize insulin, timely detection of SYK level has important implications for the clinical assessment
of disease accurately. |
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