| 贾延贞 卢彩兰 常璠 唐晓慧 彭梅芳.肺炎支原体抗体阳性对咳嗽变异性哮喘患儿肺功能的影响研究[J].现代生物医学进展英文版,2016,16(22):4329-4331. |
| 肺炎支原体抗体阳性对咳嗽变异性哮喘患儿肺功能的影响研究 |
| Influence of Mycoplasma Pneumoniae Positive Antibody on Lung Function inChildren with Cough Variant Asthma |
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| DOI： |
| 中文关键词: 咳嗽变异性哮喘 肺炎支原体 肺功能 儿童 |
| 英文关键词: Cough variant asthma Mycoplasma pneumoniae Lung function Children |
| 基金项目: |
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| 中文摘要: |
| 目的：通过探讨肺炎支原体（MP）抗体阳性感染对咳嗽变异性哮喘（CVA）患儿肺功能的影响，为临床治疗提供依据。方法：选
择2012 年6 月~2014 年6 月本院收治的CVA 患儿共60 例，依据支原体抗体检查和肺功能检测结果，分为CVA合并MP组（合
并组）和CVA组，检测两组患儿初诊时肺通气功能、支气管激发试验阳性率，分析初诊时、治疗1、3 个月后MP 抗体对肺功能第
一秒用力呼吸容积/ 用力肺活量（FEV1%）的影响。结果：初诊时两组患儿肺活量（FVC）、最大呼气峰流速（PEF）、FEV1%、最大中
段呼气流速（MMEF75/25）实测值均低于预测值（P<0.05），合并组MMEF75/25 预测值/实测值的比值较CVA 组高（P<0.05）。支气
管激发试验阳性患儿中，合并组以轻度和极轻度为主，CVA 组以重度和中度为主（P<0.05）。MP 抗体滴度持续阳性和阴性患儿
FEV1%无统计学差异(P>0.05)。结论：合并MP抗体阳性CVA患儿气道高反应性程度较低，小气道阻塞加重，对肺通气功能无影
响。 |
| 英文摘要: |
| Objective:To explore the influence of mycoplasma pneumoniae (MP) positive antibody on lung function in children
with cough variant asthma (CVA), and provide the evidence for clinical therapy.Methods:A total of 60 children with CVA, who were
treated in Xining Third People's Hospital of Qinghai Province fromJune 2012 to June 2014, were selected and divided into MP and CVA
group (combination group) and CVA group according to the inspection results of mycoplasma antibody and lung function. The lung
function and positive rates of bronchial provocation test of the two groups at first diagnosis were detected. The influence of MP
antibodies on forced expiratory volume in one second (FEV1%) in the two groups at first diagnosis and after 1 month and 3 months of
treatment were analyzed.Results:The measured values of forced vital capacity (FVC), FEV1%, peak expiratory flow (PEF), and maximal
midexpiratory flow75/25 (MMEF75/25) were lower than the predicted value in the two groups (P<0.05). The ratio of MMEF75/25
predictive value/measured value in the combination group was higher than that in the CVA group (P<0.05). In the positive results of
bronchial provocation test, combination group was mainly mild and very mild degree, while the CVA group was mainly severe and
moderate degree (P<0.05). There was no difference in FEV1% between MP antibody titers continued positive and titers continued
negative children patients (P>0.05).Conclusion:The children with CVA complicated with MP positive antibody has milder airway
hyperreactivity and heavier small airway obstruction,which has no impact on pulmonary ventilation function. |
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