| 王海生 吴锋 李文冬 张进 温洁 刘华.连续性血液净化联合血液灌流对糖尿病肾病合并难治性心衰的治疗效果分析[J].现代生物医学进展英文版,2016,16(22):4298-4301. |
| 连续性血液净化联合血液灌流对糖尿病肾病合并难治性心衰的治疗效果分析 |
| Analysis on the Effect of Continuous Blood Purification Combined withHemoperfusion on Diabetic Nephropathy Patients Complicated with Refractory Heart Failure |
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| DOI： |
| 中文关键词: 连续性血液净化 血液灌流 糖尿病肾病 难治性心衰 |
| 英文关键词: Continuous blood purification Hemoperfusion Diabetic nephropathy Refractory heart failure |
| 基金项目:陕西省自然科学基金项目(2013JM4012) |
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| 中文摘要: |
| 目的：研究连续性血液净化联合血液灌流技术治疗糖尿病肾病合并难治性心衰患者的临床效果。方法：选择我院收治的60
例糖尿病肾病合并难治性心衰患者为研究对象，按入院先后顺序随机分为对照组和观察组，每组各30 例患者，对照组患者给予
常规对症治疗，而观察组患者在常规对症治疗的基础上应用连续性血液净化联合血液灌流技术，比较两组患者的肾、心功能变化
和治疗效果。结果：治疗后，观察组的总有效率、好转率及1年存活率均明显高于对照组(P< 0.05)。对照组患者的肾、心功能指标均
较治疗前显著改善(除Scr、E/A)，而观察组的各项肾、心功能指标均较治疗前明显改善，且均明显优于对照组，差异均具有统计学
意义(P< 0.05)。结论：连续性血液净化联合血液灌流技术治疗糖尿病肾病合并难治性心衰较常规药物对症治疗更有效。 |
| 英文摘要: |
| Objective:To study the clinical effect of continuous blood purification (CBP) combined with hemoperfusion (HP) on
diabetic nephropathy (DN) patients complicated with refractory heart failure (RHF).Methods:60 cases of diabetic nephropathy
complicated with refractory heart failure were selected as the research objects. They were randomly divided into the control group and the
study group according to the order of hospitalization. There were 30 cases in each group. The control group received conventional
symptomatic treatment, while on the basis of conventional symptomatic treatment, the study group received CBP combined with HP
technique. The changes of renal and cardiac function in both groups were compared.Results:After treatment, the total effective rate,
improvement rate and the 1-year survival rate of the study group were significantly higher than those of the control group (P<0.05). The
renal and cardiac function indexes of the control group were significantly improved than before treatment (except Scr and E/A). While
each renal and cardiac function index of the study group were significantly improved than before treatment, and were significantly better
than those of the control group, the difference was statistically significant (P<0.05).Conclusion:CBP combined with HP was more
effective than conventional drugs symptomatic treatment in the treatment of DN complicated with RHF. |
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