| 李顺钧 李云霞 王慧 浦苏颖 汤跃宇 聂志余.老年急性脑梗死患者血清CRP, FG, LP(a)变化研究[J].现代生物医学进展英文版,2016,16(22):4260-4262. |
| 老年急性脑梗死患者血清CRP, FG, LP(a)变化研究 |
| Detection of SerumCRP, FG and LP(a) in Elderly Patients with AcuteCerebral Infarction |
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| DOI： |
| 中文关键词: 急性脑梗死 血清C 反应蛋白 纤维蛋白原 脂蛋白（a） |
| 英文关键词: Acute cerebral infarction Serumc-reactive protein Fibrinogen Lipoprotein(a) |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨老年急性脑梗死患者检测血清C反应蛋白（CRP）、纤维蛋白原（FG）及脂蛋白（a）（LP(a)）的变化及意义。方法：选
择2013 年12 月-2014 年12 月在我院就诊的年龄≥ 60 岁的急性脑梗死患者90 例作为实验组，根据中国脑卒中患者临床神经功
能缺损程度评分标准（NDS），分为轻型、中型和重型；根据病灶直径及Adama 分型法分为腔隙性脑梗死、小梗死和大梗死，另外选
择90 例健康老人为对照组。测定所有受试者血清中的CRP、FG 及LP（a）的水平，并比较它们在实验组与对照组、实验组不同严重
程度和不同病变类型的患者中的差异。结果：实验组血清CRP、FG 和LP(a)的水平高于对照组，且差异具有统计学意义（P<0.05）；
重型患者血清CRP、FG 和LP(a)水平明显高于中型患者，中型患者显著高于轻型患者，且差异均有统计学意义（P<0.05）；大梗死患
者血清CRP、FG 和LP(a)水平明显高于小梗死患者，小梗死患者显著高于腔隙性梗死患者，且差异均有统计意义（P<0.05）。结论：
血清CRP、FG 和LP(a)水平异常升高与老年急性脑梗死的发生发展密切相关。 |
| 英文摘要: |
| Objective:To explore the change and significance of serum c-reactive protein (CRP), fibrinogen(FG) and lipoprotein
(a) (LP (a)) detection in elderly patients with acute cerebral infarction.Methods:A total of 90 elderly patients with acute cerebral
infarction, who were treated in Tongji Hospital Affiliated to Tongji University from December 2013 to December 2014, were chosen as
experimental group, which was divided into light, medium and severe group according to the neurological deficit score (NDS) standard;
divided into lacunar infarction, small infarction and large infarction group according to the lesion size and Adama classification method.
In addition, 90 healthy elderly persons were chosen as control group. The levels of serum CRP, FG and LP (a) of all the subjects were
detected, and their differences between the experimental group and the control group, and between the patients with different severity and
lesion size in the experimental group were compared.Results:The levels of serum CRP, FG and LP (a) of the experimental group were
higher than those of the control group, the difference was statistically significant(P<0.05). The levels of serum CRP, FG and LP(a) in the
severe group were significantly higher than those in the mediumgroup, and the levels of serumCRP, FG and LP (a) in the mediumgroup
were significantly higher than those in the light group, the differences were statistically significant (P<0.05). The levels of serumCRP, FG
and LP(a) in the large infarction group were significantly higher than those in the small infarction group, and the levels of serumCRP, FG
and LP (a) in the small group were significantly higher than those in the lacunar infarction group, the differences were statistically
significant (P<0.05).Conclusion:The abnormal elevation of serum CRP, FG and LP (a) levels is closely related to the occurrence and
development of elderly patients with acute cerebral infarction. |
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