| 赵晓龙 孟胜蓝 蔡云婷 张景阁 牛会军△.TK1在肺癌患者血清中的表达水平及其与肿瘤临床病理特征及预后的关系[J].现代生物医学进展英文版,2016,16(22):4256-4259. |
| TK1在肺癌患者血清中的表达水平及其与肿瘤临床病理特征及预后的关系 |
| Expression of TK1 in Serumof Patients with Lung Cancer and the Relationshipof TK1 with Clinicopathologic Features and Prognosis of Tumor |
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| DOI： |
| 中文关键词: 胸腺嘧啶核苷激酶 肺癌 远处转移 生存率 |
| 英文关键词: TK1 Lung cancer Distant metastasis Survival rate |
| 基金项目:国家自然科学基金项目（30200123） |
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| 中文摘要: |
| 目的：探讨肺癌患者血清胸腺嘧啶核苷激酶1（TK1）与肿瘤临床病理特征及预后的关系。方法：选择2012 年1 月-2014 年1
月在我院接受治疗的肺癌患者79例作为研究对象，另选择同期在我院接受健康体检的志愿者53 例作为对照组。采用化学发光
法检测两组研究对象血清中TK1 的表达情况，并分析TK1 表达与肿瘤临床病理特征及预后的关系。结果：TK1 在肺癌患者血清
中的阳性表达率（56.96%）显著高于健康对照组（16.98%），差异具有统计学意义（P<0.05）。肿瘤分期为晚期的患者血清中TK1 的
阳性表达率高于肿瘤分期为早期的肺癌患者，差异具有统计学意义（P<0.05）；肿瘤远处转移的患者血清中TK1 的阳性表达率高
于未发生远处转移的患者，差异具有统计学意义（P<0.05）。TK1 在性别、抽烟史、淋巴结转移及病理类型不同患者血清中的阳性表
达率比较，差异无统计学意义（P>0.05）。TK1 阳性患者两年生存率（42.22%）低于TK1 阴性患者（64.71%），差异具有统计学意义
（P<0.05）。结论：肺癌患者血清中TK1 呈高表达，其表达水平与肿瘤远处转移、TMN 分期及预后有关。 |
| 英文摘要: |
| Objective:To investigate the serum levels of thymidine kinase-1 of patients with lung cancer and the relationship
between the clinicopathological features and prognosis.Methods:79 cases with lung cancer who were treated in our hospital from
January 2012 to January 2014 were selected as the research objects, and another 53 healthy people who had taken the examination in our
hospital were selected as the control group. Then the expressions of TK1 in serum of patients in the two groups were detected by
chemiluminescence, and the relationship between TK1 expression and clinicopathological characteristics and prognosis of tumor was
analyzed.Results:The positive expression rate of TK1 in the serum of patients with lung cancer was 56.96%, which was higher than
16.98% of the control group, and the difference was statistically significant (P<0.05); The positive expression rate of patients with
advanced lung cancer was higher than that of the patients with early lung cancer, and the difference was statistically significant (P<0.05);
The positive expression rate of patients with distant metastasis was higher than that of the patients without distant metastasis, and the
difference was statistically significant (P<0.05); There was no statistically significant difference about the positive expression rate of
patients with different gender, smoking history, lymphatic metastasis and pathological types (P>0.05); The two-years' survival rate of
patients with positive expression of TK1 was 42.22%, which was lower than 64.71%of patients with negative expression of TK1, and the
difference was statistically significant (P<0.05).Conclusion:The high expression of TK1 in serum of patients with lung cancer has
closely relationship with tumor metastasis, TMN stages and clinical prognosis. |
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