| 林洁 孔晋亮 黄天霞 刘凤鸣 于虹.呼吸机相关性肺炎的常见病原菌耐药性分析[J].现代生物医学进展英文版,2016,16(21):4075-4078. |
| 呼吸机相关性肺炎的常见病原菌耐药性分析 |
| Analysis on the Common Pathogenic Bacteria of Ventilator AssociatedPneumonia and the Drug Resistance* |
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| DOI： |
| 中文关键词: 呼吸机相关性肺炎 病原菌 耐药性 |
| 英文关键词: Ventilator associated pneumonia Pathogenic bacteria Drug resistance |
| 基金项目:广西壮族自治区卫生厅资助项目（Z2014479） |
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| 中文摘要: |
| 目的：探讨呼吸机相关性肺炎(VAP)的常见病原菌并分析其耐药性，为临床治疗提供依据。方法：选取我院收治的135 例
VAP患者的临床资料，分析其病原菌分布以及抗菌药物的耐药性。结果：135 例患者中共分离出183 株病原菌，其中革兰氏阴性
菌135 株（占73.77%），革兰氏阳性细菌33 株（占18.03%），真菌15 株（占8.20%）。革兰氏阴性菌主要为鲍曼不动杆菌，占
35.52%，革兰氏阳性细菌主要为金黄色葡萄球菌，占9.84%，革兰阳性菌无一对万古霉素耐药，除了米诺环素总耐药率为42.42%
外，其余病原菌对于常用的药物总耐药率均大于60.0%，革兰阴性菌普遍存在多药耐药现象。结论：引起VAP 患者感染的主要致
病菌为革兰阴性菌群，且存在严重的多重耐药现象，在临床上应加强对VAP 疾病的预防和控制，合理应用抗菌药物。 |
| 英文摘要: |
| Objective:To study the common pathogenic bacteria of ventilator associated pneumonia (VAP) and to analyze its drug
resistance, so as to provide data for clinical treatment.Methods:The clinical data of 135 patients with VAP in our hospital were retrospectively
analyzed. Their pathogenic bacteria distribution and antimicrobial resistance were investigated.Results:Totally, 183 strains of
pathogenic bacteria was isolated from 135 patients. Of them, there were 135 strains (73.77%) of gram-negative bacteria, 33 (18.03%)
strains of grampositive bacteria, 15 strains (8.20%) of fungi. Gram-negative bacteria mainly included (35.52%).
And gram-positive bacteria mainly included (9.84%). There was no vancomycin resistance among gram positive
bacteria. Except the total resistance percentage to minocycline was 42.42%, the total resistance to commonly drugs in rest of the
pathogenic bacteria all were greater than 60.0%. Gram-negative bacteria had a widespread multi-resistant phenomenon.Conclusion:The
main pathogenic bacteria causing infections in VAP patients were gram-negative bacteria, and there were serious multi-drug resistance
phenomenon. We should strengthen the prevention and control of VAP and make reasonable use of the antimicrobial agents. |
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