| 朱晓妍 朱靖宇 申星杰 姜雅堃 路亮.内镜黏膜下剥离术治疗消化系统早癌及癌前病变的临床疗效[J].现代生物医学进展英文版,2016,16(20):3873-3875. |
| 内镜黏膜下剥离术治疗消化系统早癌及癌前病变的临床疗效 |
| Clinical Effect of Endoscopic Submucosal Dissection on Treatment ofGastrointestinal Carcinoma in Early Stage and Precancerous Lesions |
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| DOI： |
| 中文关键词: 消化道肿瘤 早癌 癌前病变 内镜黏膜下剥离术 复发及转移 |
| 英文关键词: Gastrointestinal carcinoma Carcinoma in early stage Precancerous lesion Endoscopic submucosal dissection Recurrence and metastasis |
| 基金项目:山东省科技发展计划基金项目(32050128) |
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| 中文摘要: |
| 目的：探讨内镜黏膜下剥离术（ESD）对消化道早癌及癌前病变的治疗效果。方法：选择2013 年8 月至2014年8 月在我院接
受治疗的消化道肿瘤患者79 例作为研究对象，根据手术方法不同将所选患者分为ESD 组（49 例）和对照组（30 例）。ESD 组患者
采用内镜黏膜下剥离术治疗，对照组采用传统手术治疗。观察并比较两组患者的手术时间、治愈性切除率、整块完整切除率、术后
并发症的发生率及复发、转移情况。结果：ESD 组患者的手术时间少于对照组，差异具有统计学意义（P<0.05）；两组患者手术治愈
性切除率均为100%，差异无统计学意义（P>0.05）；ESD组手术整块完整切除率（63.27%）低于对照组（86.67%），差异具有统计学
意义（P<0.05）。ESD组患者术后并发症的发生率（4.08%）显著低于对照组（13.3%），差异具有统计学意义（P<0.05）。两组患者术后
一年内均未出现原发病灶转移及复发。结论：ESD 治疗消化道早癌及癌前病变的临床疗效较好，与传统手术相比，ESD 手术并发
症较少、且安全性较高，更加适宜临床推广及应用。 |
| 英文摘要: |
| Objective:To investigate the clinical effect of endoscopic submucosal dissection (ESD) on the treatment of
gastrointestinal carcinoma in early stage and precancerous lesions.Methods:79 patients with gastrointestinal carcinoma who were treated
in our hospital from August 2013 to August 2014 were selected as the research subjects. According to the different operation methods,
the selected patients were divided into the ESD group (49 cases) and the control group (30 cases). The patients in ESD group were treated
with endoscopic submucosal dissection, and the patients in the control group were treated with conventional surgery. Then the operation
time, curative resection rate, the whole complete resection rate, postoperative complication and recurrence and metastasis in the two
groups were observed and compared.Results:The operation time in the ESD group was less than that of the control group, and the
difference was statistically significant (P<0.05); The curative resection rate in the two groups were 100%, and there was no statistically
significant difference (P>0.05); The whole complete resection rate in the ESD group was 63.27%which was lower than 86.67% of the
control group, and the difference was statistically significant (P<0.05). The incidence of postoperative complications in the ESD group
was 4.08% which was lower than 13.3% in the control group, and the difference was statistically significant (P<0.05). There was no
metastasis and recurrence of primary lesions in the two groups after the operation for one year.Conclusion:The clinical effect of ESD on
the treatment of gastrointestinal carcinoma and precancerous lesion is better. Compared with the conventional operation, ESD has less
complications and higher safety, which is more suitable for clinical application. |
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