| 李亚静 郝峻烽 刘娇娜 张晓玲 白久旭 曹宁.血液透析血压及其变异性与患者预后的相关性分析[J].现代生物医学进展英文版,2016,16(19):3720-3723. |
| 血液透析血压及其变异性与患者预后的相关性分析 |
| Analysis of the Association between Blood Pressure Variability duringDialysis and Prognosis of Patients treated by Maintenance Haemodialysis |
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| DOI： |
| 中文关键词: 维持性血液透析 血压 变异性 预后 |
| 英文关键词: Maintenance hemodialysis Blood pressure Variability Mortality |
| 基金项目:全军医学科技青年培育项目计划课题（13QNP002） |
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| 中文摘要: |
| 目的：探讨血液透析前后和血液透析过程中血压及其变异性与患者预后的相关性。方法：选取沈阳军区总医院血液透析中
心2010 年1 月1 日至2013年12月31日收治的维持性血液透析患者，收集并对比随访期内生存及死亡患者的自然信息及临床
资料，评估血液透析过程中患者血压及其变异程度与患者预后的关系。结果：共有269例患者纳入研究，经过4 年随访共死亡83
(30.86%)例。死亡组年龄显著大于存活组(64.92± 13.24 岁比49.89± 12.86 岁，P=0.000)，而透析年限显著短于存活组(2.60± 2.56
年比7.25± 4.14 年，P=0.000)。死亡组透析前SBP(P=0.001)、DBP(P=0.000)、MAP(P=0.000)均显著高于存活组。两组间透析后SBP、
DBP、MAP比较均无显著差异。死亡组△SBP(P=0.026)、△DBP(P=0.001)、△MAP(P=0.001)幅度显著大于存活组。死亡组透析前
SBP 变异率显著高于存活组(P=0.001)；死亡组透析后SBP 变异率(P=0.000)、DBP 变异率(P=0.014)、MAP 变异率(P=0.005)均高于
存活组。死亡组每次透析前各时间点间SBP 变异率(0.12± 0.04 mmHg 比0.09± 0.03 mmHg，P=0.000)与MAP 变异率(0.10± 0.03
mmHg 比0.09± 0.03 mmHg，P=0.001)显著高于非死亡组。结论：维持性血液透析患者透析前血压、透析前后血压改变幅度、透析
前后血压变异率、每次透析各时间点间血压变异率等与全因死亡相关。 |
| 英文摘要: |
| Objective:To determine the association between blood pressure variability during dialysis and prognosis of patients
treated by maintenance haemodialysis.Methods:A longitudinal observational study of patients commencing haemodialysis from 2010 to
2013 in our blood purification center was performed. The relationship between blood pressure variability during dialysis and mortality
was assessed.Results:Of 269 patients enrolled, 83 (30.86%) patients died during the follow-up of 4 years. Pre-dialytic SBP(P=0.001),
DBP (P=0.000), MAP (P=0.000) were significantly higher in the death group. No significant difference was found in Post-dialytic SBP,
DBP and MAP between the two groups. Post-dialytic drops in SBP(P=0.026), DBP(P=0.001) and MAP(P=0.001) were more significant
in death gourp. Coefficient of variation in pre-dialytic SBP (P=0.001), Post-dialytic SBP (P=0.000), DBP (P=0.014) and MAP(P=0.005)
were significantly higher in the death group. Coefficient of variation in SBP(P=0.000) and MAP(P=0.001) were significantly higher in the
death group.Conclusion:Our study shows that pre-dialysis systolic blood pressure, blood pressure variability during dialysis were associated
with all-cause mortality of patients treated by maintenance haemodialysis. |
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