| 蔡超 陈珍 王崇全 王治校 毛山 陈孝强.氨氯地平、比索洛尔对高血压合并心绞痛患者CAP及IMT 的影响[J].现代生物医学进展英文版,2016,16(18):3530-3532. |
| 氨氯地平、比索洛尔对高血压合并心绞痛患者CAP及IMT 的影响 |
| Effect of Amlodipine and Bisoprolol on the CAP and IMT of HypertensivePatients combined with Angina Pectoris |
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| DOI： |
| 中文关键词: 氨氯地平 比索洛尔 高血压 心绞痛 中心动脉压 颈动脉内中膜厚度 |
| 英文关键词: Amlodipine Bisoprolol Hypertension Angina pectoris CAP IMT |
| 基金项目:湖北省自然科学基金项目(2000J064) |
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| 中文摘要: |
| 目的：比较氨氯地平、比索洛尔对高血压合并心绞痛患者中心动脉压(central artery pressure，CAP) 及颈动脉内中膜厚度
(intima-media thickness，IMT)的影响。方法：选择我院2013 年8 月-2014年9 月收治的高血压合并心绞痛患者76例，随机分为观
察组和对照组，各38 例。观察组给予氨氯地平5 mg/d，对照组给予比索洛尔2.5 mg/d，疗程均为1 年。测定并对比两组治疗前后血
压、CAP、IMT 变化情况以及心绞痛的治疗效果。结果：观察组治疗后CAP 收缩压、舒张压、IMT 分别为(130.36± 5.09)mmHg、
(73.38± 5.76)mmHg、(0.89± 0.08)mm，均明显低于对照组的(144.82± 6.54)mmHg、(84.89± 6.14)mmHg、(1.01± 0.12)mm，差异均有
统计学意义(P＜0.05)。观察组治疗总有效率为89.47%，高于对照组的76.32%，但差异无统计学意义(P＞0.05)。结论：氨氯地平与
比索洛尔治疗高血压合并心绞痛的临床疗效相当，但氨氯地平在降低高血压合并心绞痛患者CAP、IMT 方面的效果优于比索洛
尔。 |
| 英文摘要: |
| Objective:To compare the effect of amlodipine and bisoprolol on the central artery pressure (CAP) and carotid artery
intima-media thickness (IMT) of hypertensive patients combined with angina pectoris.Methods:76 cases of hypertensive patients
combined with angina pectoris admitted in our hospital fromAugust 2013 to September 2014 were randomly divided into the observation
group and the control group, 38 cases in each group. The observation group was given amlodipine 5 mg/d, while the control group was
given bisoprolol 2.5 mg/d for 1 years. The changes of blood pressure, CAP and IMT before and after treatment in two groups were
measured and compared, and the therapeutic effect of angina pectoris was measured and compared.Results:In the observation group
after treatment, the systolic blood pressure, diastolic blood pressure and IMT were (130.36 ± 5.09) mmHg (73.38± 5.76) mmHg (0.89±
0.08) mm, which were lower than those of the control group (144.82 ± 6.54) mmHg, (84.89 ± 6.14) mmHg and (1.01± 0.12) mm, the
differences were statistically significant (P<0.05). And the total efficiency of observation group was 89.47%, which was higher than that
of the control group(76.32%), but no statistically significant difference was found between two groups(P>0.05).Conclusion:The clinical
efficacy of amlodipine was equal to bisoprolol in the treatment of hypertensive patients combined with angina pectoris, but it could more
effectively reduce the CAP and IMT than bisoprolol. |
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