| 孟根托娅 陈凤英△ 牛君义 谢秀峰 郑奇.急性非ST 段抬高性心肌梗死患者血清尿酸水平与N末端B 型钠尿肽原的相关性分析[J].现代生物医学进展英文版,2016,16(18):3527-3529. |
| 急性非ST 段抬高性心肌梗死患者血清尿酸水平与N末端B 型钠尿肽原的相关性分析 |
| Correlation Analysis on Serum Uric Acid Level and NT-proBNP inNon-ST-segment Elevation Acute Myocardial Infarction |
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| DOI： |
| 中文关键词: 急性非ST 段抬高性心肌梗死 尿酸 N 末端B 型钠尿肽原 |
| 英文关键词: Non-ST-segment elevation acute myocardial infarction Uric acid NT-proBNP |
| 基金项目:内蒙古医科大学青年创新基金(YKD2014QNCX023) |
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| 中文摘要: |
| 目的：探讨急性非ST 段抬高性心肌梗死(NSTEMI)患者血清尿酸水平与N 末端B型钠尿肽原(NT-proBNP)的相关性分析。
方法：将143 例NSTEMI患者按照入院时血清尿酸四分位数分为四组：Ⅰ组(尿酸＜284.18 滋mol/L)、Ⅱ组(284.19～336.53 滋mol/L)，
Ⅲ组(336.54～390.78 滋mol/L)，Ⅳ (尿酸＞390.79 滋mol/L)；按照血清NT-proBNP 中位数分为2 组：NT-proBNP＜571.56 pg/mL 组
和NT-proBNP≥ 571.56 pg/mL 组；比较各组相关指标的差异。结果：Ⅰ组、Ⅱ组、Ⅲ组及Ⅳ组四组的NT-proBNP、GRACE危险评
分、CK-MB、LEVF、cTnI 比较统计学差异(P＜0.05)，Ⅳ组NT-proBNP、GRACE 危险评分、cTnI、CK-MB 高于Ⅰ组、Ⅱ组、Ⅲ组，Ⅲ
组高于Ⅰ组、Ⅱ组(P＜0.05)；NT-proBNP≥ 571.56 pg/mL 组血清尿酸、GRACE 危险评分、cTnI、CK-MB 高于NT-proBNP＜571.56
pg/mL组(P＜0.05)。血清尿酸分别与NT-proBNP、GRACE 危险评分呈现正相关(P＜0.05)。结论：血清尿酸水平与NSTEMI患者
的NT-proBNP 密切相关，临床检测血清尿酸水平对于评估NSTEMI患者NT-proBNP水平具有重要的意义。 |
| 英文摘要: |
| Objective:To explore the correlation of serum uric acid level and N-terminal pro-B-type natriuretic peptide
(NT-proBNP) in non-ST-segment elevation acute myocardial infarction (NSTEMI).Methods:According to quartiles of serum uric acid
on admission, the 143 patients with NSTEMI were divided into four groups: groupⅠ (uric acid < 284.18 umol/L), group Ⅱ (284.19 ~
336.53 umol/L), group Ⅲ(336.54 ~ 390.78 umol/L), group Ⅳ (uric acid > 390.79 umol/L). According to the median serumNT-proBNP,
they were divided into two groups: the NT-proBNP < 571.56 pg/mL group and the NT-proBNP ≥ 571.56 pg/mL group. Compare the
difference of related indicators between the groups.Results:The NT-proBNP, GRACE risk score, CK-MB, LEVF and cTnI were
statistically different between the four groups (P <0.05). The NT-proBNP, GRACE risk score, cTnI and CK-MB in group Ⅳ were higher
than in groupⅠ, Ⅱ and Ⅲ, and those in group Ⅲ were higher than in groupⅠand Ⅱ (P<0.05). The serum uric acid level, GRACE risk
score, cTnI and CK-MB were higher in NT-proBNP ≥ 571.56 pg/mL group than in NT-proBNP < 571.56 pg/mL group (P<0.05).
Multiple linear regression analysis showed that the level of serum uric acid was positively related with the NT-proBNP levels and the
GRACE risk score respectively (P<0.05).Conclusion:The serum uric acid level is closely related to the NT-proBNP levels of NSTEMI
patients. Clinical detection of serumuric acid levels has great significance for evaluating NT-proBNP levels of NSTEMI patients. |
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