| 白马恒 马琼 韩康 刘增亮 邢永军.miRNA-192 在骨肉瘤临床样本中的表达及与各临床要素之间关系的相关研究[J].现代生物医学进展英文版,2016,16(18):3504-3507. |
| miRNA-192 在骨肉瘤临床样本中的表达及与各临床要素之间关系的相关研究 |
| Research on Expression of miRNA-192 in Human Osteosarcoma and theRelationship between It and Clinicopathological Features |
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| DOI： |
| 中文关键词: miRNA-192 生存 转移 骨肉瘤 |
| 英文关键词: MicroRNA-192 Mortality Metastasis Osteosarcoma |
| 基金项目:国家自然科学基金项目(81201633)；济南军区总医院院长基金项目（2015ZX01） |
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| 中文摘要: |
| 目的：观察miRNA-192 在骨肉瘤中与各临床要素之间的关联，分析其与骨肉瘤患者生存情况之间的关系，为研究
miRNA-192在骨肉瘤中的作用及可能的临床应用提供理论依据。方法：选取50 例骨肉瘤新鲜样本组织及瘤旁组织，使用荧光
RT-PCR 的方法对样本中的miRNA-192 的含量进行检测，结合详实的随访资料，分析miRNA-192 与性别、年龄等临床要素之间
的关系。通过生存分析的方法，分析miRNA-192 与患者生存情况之间的关系。结果：miRNA-192 与患者的年龄，肿瘤大小，分期，
生存时间等有明显的统计学关联(P<0.05),包括年龄(P = 0.028)，临床分期(P = 0.007)，远端转移(P = 0.013)和生存率(P=0.001)。结
论：在临床样本中，miRNA-192 与患者的多项临床要素有显著性关联，包括年龄，临床分期，远端转移和生存率，为接下来关于
miRNA-192在骨肉瘤中的各项研究，特别是作为生物标记信号的临床应用奠定了良好的实验基础。 |
| 英文摘要: |
| Objective:To explore and describe the relationship of miRNA-192 function and clinicopathological features in human
osteosarcoma and analyze the relationship between miRNA-192 and mortality, which support some theoretical basis for osteosarcoma
treatment and element experience for further research.Methods:Real-time quantitative PCR analysis were used in 50 clinical
osteosarcoma samples which were followed up. Then the relationship of miRNA-192 function and clinicopathological features (like sex,
age) in human osteosarcoma were explored.Results:We found that there were statistically significant relationships between miRNA-192
expression and some clinicopathological features of osteosarcoma, including age(P = 0.028), clinical stage (P = 0.007), distant metastasis
(P = 0.013) and patient mortality (P=0.001).Conclusion:In clinical specimens, miRNA-192 expression levels were correlated with some
clinicopathological features of osteosarcoma, including age, clinical stage, distant metastasis and patient mortality, which provided the
theoretical basis for the next study especially the biological therapy of miRNA-192 in the osteosarcoma. |
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