| 林建辉 陈怡 李芹 刘豫瑞.骨髓间充质干细胞抗肝纤维化的研究进展[J].现代生物医学进展英文版,2016,16(17):3398-3400. |
| 骨髓间充质干细胞抗肝纤维化的研究进展 |
| Progress in Researches of Mesenchymal StemCells for Anti-liver Fibrosis |
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| DOI： |
| 中文关键词: 肝细胞纤维化 骨髓间充质干细胞 细胞治疗 骨髓干细胞动员 |
| 英文关键词: Liver fibrosis MSCs Cell therapy Stemcell mobilization |
| 基金项目:福州市科学技术局基金项目（2014-S-139-10）；国家十二五重大专项子课题（2013ZX10005002-001-002） |
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| 中文摘要: |
| 肝纤维化及其终末病变肝硬化已严重危害全球人类健康，虽然慢性肝病的治疗手段和抗肝纤维化药物的研究已取得了很
大进展，肝移植依然是最有效的治疗方案，但器官的紧缺却是一个现实问题。目前寻找有效的干预手段进行抗肝纤维化治疗已越
来越受到大家的关注。近些年，大量基础及临床研究均证实在一定条件下利用骨髓间充质干细胞(MSCs)可以抑制肝星状细胞活
化诱导其凋亡，实现肝纤维化逆转。随着干细胞技术的快速发展，基于骨髓间充质干细胞(MSCs) 的细胞疗法在肝纤维化治疗领域
的研究与应用已成为一个充满生命力的新方向。本文将对肝纤维化及基于MSCs的治疗机制进展及其应用进行综述。 |
| 英文摘要: |
| Liver fibrosis and its end stage cirrhosis are quite serious throughout the whole world. So far we have made breakthroughs
in chronic liver diseases and anti-fibrosis but orthotopic liver transplantation is always the most effective therapy. However organ
shortage is a reality. There has been increasing attention on finding the most appropriate way on anti-fibrosis nowadays. In recent
years plenty of basic and clinical researches have been done identifying that cell- based therapy using mesenchymal stem cells (MSCs)
may inhibit the proliferative, fibrogenic function and apoptosis of activated HSCs reversaling hepatic fibrosis. With the development of
stem cells, the therapy based on MSCs may represent an attractive therapeutic option. Therefore, this article is mainly about liver fibrosis
the mechanisms and the appliance on the therapy based o on MSCs. |
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