| 王荣 贾爱华 井长信 刘新艳 马江卫 梁潇.西北地区初发2 型糖尿病人口胰岛功能的现状调查[J].现代生物医学进展英文版,2016,16(17):3363-3365. |
| 西北地区初发2 型糖尿病人口胰岛功能的现状调查 |
| Investigation of the Status Quo of Islets Function of Incipient DiabeticPatients in Yulin City Rural Population |
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| DOI： |
| 中文关键词: 初发2 型糖尿病 胰岛功能 病程 |
| 英文关键词: Incipient diabetic Islet function Course of the disease |
| 基金项目:国家自然科学基金项目（81070615） |
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| 中文摘要: |
| 目的：通过对榆林市初发2 型糖尿病患者的胰岛功能进行跟踪观察，探讨初发2 型糖尿病患者胰岛功能的变化特点。方法：
选取榆林市1220 例初发2 型糖尿病患者作为观察对象，跟踪随访12 个月，在就诊后的3 个月、6 个月及12 个月时，检测全部患
者的血糖水平、Ｃ- 肽释放量，计算胰岛素分泌指数（HOMA-beta）及胰岛素抵抗指数（HOMA-IR），观察总结患者的胰岛功能变化特
点。结果：随访期间，糖尿病患者Ｃ-肽释放量持续降低，且在就诊后3 个月内，Ｃ-肽释放量下降明显（P<0.05），与就诊后6 个月
时及12 个月时比较，糖尿病患者胰岛素放量持续降低，就诊后3 个月内下降最明显（P<0.05）；患者胰岛素分泌指数持续降低
（P<0.05），胰岛素抵抗指数持续升高（P<0.05），且与6 个月时和12 个月时比较，3 个月时变化幅度最为显著（P<0.05）。结论：随着
病程的延长，初发2 型糖尿病患者胰岛功能逐渐降低，二者具有显著相关性，且3 个月内患者的胰岛功能下降最为显著。 |
| 英文摘要: |
| Objective:Through the Yulin City Rural of islet function in patients with incipient diabetic tracking observation, to
study the change of islet function in patients with incipient diabetic characteristics.Methods:Selection of Yulin City Rural at the beginning
of 1220 cases of patients with diabetes mellitus as research object, 12 months follow-up, the clinic after 3 months, 6 months and 12
months, all patients to detect blood sugar change, c-peptide release quantity, calculate insulin secretion index (HOMA-beta) and insulin
resistance index (HOMA IR), summarizes the characteristic of islet function in patients with changes.Results:During the follow-up period,
the amount of C-peptide release in patients with diabetes decreased continuously, and the amount of C-decreased significantly in the 3
months after treatment (P<0.05). Compared with 6 months after treatment and 12 months after treatment, the volume of insulin in diabetic
patients continued to decrease, the most obvious decline in 3 months after treatment (P<0.05).Conclusion:With the extension of course,
the incipient diabetic islets function gradually reduce, both have significant correlation, and patients within 3 months of the most significant
the islet function. |
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