| 杨永祥 张慜 马珊 范玲玲 王圣元 王均刚 赵思佳 李柱一△.循环滤泡辅助性T细胞亚型与重症肌无力患者临床特点之间的相关性分析[J].现代生物医学进展英文版,2016,16(17):3334-3337. |
| 循环滤泡辅助性T细胞亚型与重症肌无力患者临床特点之间的相关性分析 |
| Analysis of the Correlation of Circulating Follicular Helper T Cells Subsetswith Clinical Features of Myasthenia Gravis |
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| DOI： |
| 中文关键词: 重症肌无力 循环滤泡辅助性T 细胞 临床特点 |
| 英文关键词: Myasthenia gravis Circulating follicular helper T cell Clinical feature |
| 基金项目:国家自然科学基金项目（81301069；31270952） |
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| 中文摘要: |
| 目的：分析循环滤泡辅助性T(cTfh)细胞亚型与重症肌无力(MG)患者临床特点之间的关系。方法：横断面研究30 例MG 患
者外周血cTfh 细胞各个亚型百分比和临床特点之间的关系。cTfh 细胞亚型的百分比是通过流式细胞术获取的。MG 患者的临床
特点包括性别、年龄、病程、胸腺情况、美国重症肌无力协会(MGFA)分型和重症肌无力量化(QMG)评分。结果：CD4+CXCR5+
ICOS+、CD4+CXCR5+PD-1+和CD4+CXCR5+CXCR3-CCR6+(Th17 样)cTfh细胞亚型百分比与QMG 评分之间存在正相关关系；全身
型重症肌无力(GMG)患者在CD4+CXCR5+ICOS+、CD4+CXCR5+PD-1+和Th17 样cTfh 细胞亚型百分比要高于眼肌型重症肌无力
(OMG)患者，OMG 患者在CD4+CXCR5+CXCR3-CCR6-(Th2样)cTfh 亚型细胞百分比要高于GMG患者。cTfh 细胞各个亚型百分
比与MG 患者的性别、年龄、病程、胸腺情况均无显著相关性。结论：CD4+CXCR5+ICOS+、CD4+CXCR5+PD-1+和Th17 样cTfh 细胞
亚型百分比与MG 病情严重性间存在正相关关系，提示cTfh 细胞与MG之间的密切关系。 |
| 英文摘要: |
| Objective:To analyze the correlation of circulating follicular helperT (cTfh) cells subsets with clinical features of
myasthenia gravis (MG).Methods:The correlations of peripheral blood cTfh cells subsets with clinical features of 30 cases ofMGpatients
were studied cross-sectionally. Frequencies of the subsets of cTfh cells were determined by flow cytometry. Clinical features included
gender, age, disease duration, the situation of thymus, Myasthenia Gravis Foundation of America (MGFA) clinical classification and
Quantitative Myasthenia Gravis (QMG) score.Results:There were positive correlations between the frequencies of CD4+CXCR5+ICOS+,
CD4+CXCR5+PD-1+, CD4+CXCR5+CXCR3-CCR6+ (cTfh-Th17) cells and the QMG scores. The frequencies of CD4+CXCR5+ICOS+,
CD4+CXCR5+PD-1+, cTfh-Th17 cells in generalized MG (GMG) were higher than those of ocular MG (OMG). The frequencies of
cTfh-Th2 cells in ocular MG (OMG) were higher than those of generalized MG (GMG). There was no correlation of frequencies of cTfh
cells subsets with gender, age, disease duration and the situation of thymus.Conclusion:There were positive correlations between the
frequencies of CD4+CXCR5+ICOS+, CD4+CXCR5+PD-1+, cTfh-Th17 cells and the severity of MG, which indicated the close relationship
between the cTfh cell and MG. |
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