| 王丽辉 陈芳 郑华城 杨花芳 孙素真 杜雅坤.唑尼沙胺单药治疗儿童癫痫疗效及骨代谢的影响[J].现代生物医学进展英文版,2016,16(15):2959-2961. |
| 唑尼沙胺单药治疗儿童癫痫疗效及骨代谢的影响 |
| Clinical Efficacy of Zonisamide Monotherapy and Its Effect on BoneMetabolismof Epilepsy Children |
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| DOI： |
| 中文关键词: 唑尼沙胺 癫痫 疗效 骨代谢 |
| 英文关键词: Zonisamide Epilepsy Curative effect Bone metabolism |
| 基金项目:河北省卫生厅科研基金项目(20130396) |
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| 中文摘要: |
| 目的：探讨唑尼沙胺(Zonisamide ZNS)对儿童癫痫疗效及骨代谢的影响。方法：选择2013 年3 月至2014 年3月到河北省儿
童医院神经内科门诊及病房就诊的新诊断癫痫患儿，其中男性36 名，女性24 名，年龄在2-14 岁，给予唑尼沙胺单药治疗，分别于
服药前、服药后6 月查血甲状旁腺素、血钙、磷、碱性磷酸酶和骨密度测定，并与对照组进行对比。对照组选择就诊于儿保科年龄、
性别相匹配的正常儿童。并分析癫痫患儿发作频率及严重程度，评估疗效。结果：唑尼沙胺治疗53 例癫痫患儿中，42 例（79.2）无
发作，8 例（15%）有效，3 例（5.7%）无效。且对骨代谢相关血清学指标、骨密度无明显影响。结论：ZNS对儿童癫痫有显著疗效，是
一种广谱、耐受良好的抗癫痫药。 |
| 英文摘要: |
| Objective:To study the influence of zonisamide (ZNS) on the curative effect of epileptic children and their bone
metabolism.Methods:The newly diagnosed epilepsy patients in our hospital were selected in this study, including 36 male and 24 female,
aged from 2 to 14 years old. They were given zonisamide monotherapy. And their blood parathyroid hormone, calcium, phosphorus,
alkaline phosphatase and bone mineral density were detected respectively before taking the medicine, at 6 months after taking this
medicine. Data were compared with that of the control group. The age and gender matched normal children fromour children's health department
were selected as control group. Analyze the epilepsy seizure frequency and severity of children and evaluate the curative effect.Results:Among the 53 epilepsy children treated with zonisamide, 42 cases (79.2%) had no attack, and 8 cases (15%) got curative effect.
Zonisamide was invalid for 3 patients (5.7%). It had no obvious effect on the bone metabolismrelated serological indexes and bone mineral
density.Conclusion:ZNS have remarkable curative effect on children epilepsy. Therefore, it is a kind of broad-spectrum antiepileptic
drugs and can be well tolerated. |
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