| 于吉祥 樊琳琳 杨彬 李禹 孟冉冉.阿托伐他汀对颈动脉狭窄并支架置入术后患者临床预后及炎症因子的影响[J].现代生物医学进展英文版,2016,16(15):2946-2948. |
| 阿托伐他汀对颈动脉狭窄并支架置入术后患者临床预后及炎症因子的影响 |
| Influence of Atorvastatin on Clinical Prognosis and Inflammatory Factors ofPatients with Carotid Stenosis Undergoing Stent Implantation |
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| DOI： |
| 中文关键词: 颈动脉狭窄 阿托伐他汀 支架 炎症因子 |
| 英文关键词: Carotid stenosis Atorvastatin Stent Inflammatory factors |
| 基金项目: |
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| 中文摘要: |
| 目的：研究阿托伐他汀对颈动脉狭窄并支架置入术后患者临床预后及炎症因子的影响。方法：选取2013 年1 月到2014 年1
月我院收治的接受支架置入术的颈动脉狭窄患者90例，按照随机数字表法将患者分为研究组和对照组，每组45 例，对照组给予
常规治疗，研究组在对照组的基础上给予阿托伐他汀治疗，连续治疗1 年，比较两组支架内再狭窄率及不良反应发生率，分析治
疗前和治疗后两组超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）水平。结果：研究组1 年内支架再狭窄率显著低于对照组，两
组比较差异具有统计学意义（P＜0.05）；治疗后两组hs-CRP 和IL-6 水平均显著低于治疗前，且研究组显著低于对照组，比较差异
具有统计学意义（P＜0.05）；两组不良反应比较无统计学意义（P＞0.05）。结论：阿托伐他汀治疗颈动脉狭窄并支架置入术患者，能
显著降低支架内再狭窄率及炎症因子水平。 |
| 英文摘要: |
| Objective:To study the influence of atorvastatin on the clinical prognosis and inflammatory factors of patients with
carotid stenosis undergoing stent implantation.Methods:A total of 90 patients with carotid stenosis, who underwent stent implantation in
First People's Hospital, Jining from January 2013 to January 2014, were randomly divided into study group (n=45) and control group
(n=45). The control group was treated with routine therapy, while the study group was added atorvastatin on the basis of control group's
therapy, with continuous treatment for 1 years. The restenosis rate and incidence of adverse reactions were compared between the two
groups; the high sensitivity-C reactive protein(hs-CRP), interleukin -6 (IL-6) levels in the two groups before and after treatment were analyzed.Results:The restenosis rate within 1 years of study group was significantly lower than that in control group, the difference was statistically
significant (P<0.05). Compared with before treatment, hs-CRP and IL-6 levels in two groups after treatment significantly decreased,
moreover, the study group was significantly lower than the control group,the differences were statistically significant(P<0.05).
There was no statistical significance in the incidence of adverse reactions between the two groups (P>0.05).Conclusion:Atorvastatin can
significantly cut down the restenosis rate and inflammatory factors levels in the treatment of patients with carotid stenosis undergoing
stent implantation. |
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