| 覃煜 陈金梅 刘晓玲 薄建华 张淑香.交替放化疗对晚期鼻咽癌患者疗效与影响因素分析[J].现代生物医学进展英文版,2016,16(15):2921-2923. |
| 交替放化疗对晚期鼻咽癌患者疗效与影响因素分析 |
| Effects and Influence Factors of the Treatment by AlternatingChemoradiotherapy for Patients with Advanced Nasopharyngeal Carcinoma |
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| DOI： |
| 中文关键词: 鼻咽癌 交替放化疗 疗效 |
| 英文关键词: Nasopharyngeal carcinoma Chemotherapy Efficacy |
| 基金项目:天津市河东区卫生局科技项目(2012BWKY019) |
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| 中文摘要: |
| 目的：评估交替放化疗（CRT）对晚期鼻咽癌（NPC）患者的疗效与影响因素。方法：选取在我院耳鼻喉科治疗的102例鼻咽癌
患者。交替使用放疗，化疗进行治疗。在102 例患者中，83 例接受顺铂（50 mg/m2/d，d1-2）和5- 氟尿嘧啶（5-Fu；800 mg/m2/d，
d1-5），而19 例患者接受卡铂（20 mg/m2/d，d6）和5-FU。结果：72（70.6%）例患者完成全部3 个化疗疗程。交替放化疗的总时间为
92（82-102）天。中位随访时间54 个月，5 年无进展生存期（PFS）为70.5%。多因素分析显示，体重减轻和化疗疗程数对PFS 有显著
影响。结论：化疗与放疗交替治疗的NPC 患者依从性好，适应性强，值得临床推广。 |
| 英文摘要: |
| Objective:To evaluate the efficacy and influence factors of the treatment by alternating chemoradiotherapy for patients
with advanced nasopharyngeal carcinoma.Methods:The 102 NPC patients treated in our hospital were included. Radiotherapy and
chemotherapy were alternately administered. Among them, 83 patients were treated with cisplatin (50 mg/m2/d, d1-2) and 5- fluorouracil
(5-Fu; 800 mg/m2/d, d1-5), and 19 patients were treated with carboplatin (20 mg/m2/d, d6) and 5-FU.Results:Totally, 72 patients
(70.6%) completed all 3 chemotherapy courses. The total time of CRT was 92 (82-102) days. Median follow-up time was 54 months, and
the rate of 5 years without progression survival (PFS) was 70.5%. Multivariate analysis showed that weight loss and the number of
chemotherapy courses had a significant effect on PFS.Conclusion:CRT treatment for NPC patients had a good compliance, adaptability,
so it is worthy of clinical promotion. |
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