| 高波 宋小英 郭浩 毕云 郑俊晨 李莉.复方丹参滴丸对冠心病合并颈动脉粥样斑块患者C-反应蛋白
及血管内皮功能的影响[J].现代生物医学进展英文版,2016,16(15):2910-2913. |
| 复方丹参滴丸对冠心病合并颈动脉粥样斑块患者C-反应蛋白
及血管内皮功能的影响 |
| Effect of Compound Danshen Dripping Pills on the C- reactive Protein andVascular Endothelial Function of Patients with Coronary Heart Disease andCarotid Atherosclerotic Plaque |
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| DOI： |
| 中文关键词: 复方丹参滴丸 冠心病合并颈动脉粥样斑块 C-反应蛋白 血管内皮 |
| 英文关键词: Compound Danshen Dripping Pills Coronary heart disease and carotid atherosclerotic plaque C- reactive protein Vascular
endothelium |
| 基金项目:教育部国家医学教育发展中心医学研究课题（2010-16-03-021） |
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| 中文摘要: |
| 目的：探讨复方丹参滴丸对冠心病合并颈动脉粥样斑块患者血管内皮功能及C- 反应蛋白(C-reactive protein，CRP)水平的影
响。方法：选取我院2012年6 月-2014 年12 月期间收治的84 例冠心病合并颈动脉粥样斑块患者作为研究对象，并按照随机数字
表法将其分为两组，各42 例。对照组患者给予阿司匹林肠溶片、他汀类药物等常规药物治疗，而试验组患者在对照组治疗的基础
上加服复方丹参滴丸进行治疗，12 周为1 个疗程。观察并比较两组患者治疗前后的血清CRP水平、肱动脉街道内皮依赖性舒张
功能(FMD)、内皮素(ET-1)、一氧化氮(NO)、血栓素B2(TXB2)以及6-酮- 前列腺素Fla(6-Keto-PGF-la)的变化情况。结果：治疗12
周后，两组患者血清中CRP 的水平相对治疗前均显著降低(P<0.05)，试验组患者降低的程度更为显著(P＜0.05)；对照组患者的
FMD、NO和6-Keto-PGF-la 指标的水平与治疗前相比较虽有升高的趋势，但均不显著(P＞0.05)，而试验组患者在上述各指标方面
的升高程度相对治疗前以及对照组均差异显著(P<0.05或P<0.01)；对照组患者的ET-1和TXB2 指标的水平与治疗前相比也有一
定的降低趋势，但均不显著(P<0.05)，而试验组患者在ET-1 和TXB2 指标方面相对治疗前以及对照组均显著降低(P<0.05 或P<0.
01)。结论：复方丹参滴丸可以显著降低冠心病合并颈动脉粥样斑块患者的血清CRP水平，同时对患者的血管内皮功能也具有明
显的改善作用。 |
| 英文摘要: |
| Objective:To evaluate the impact of Compound Danshen Dripping Pills on C- reactive protein (CRP) level and vascular
endothelial function of patients with coronary heart disease and carotid atherosclerotic plaque.Methods:84 patients with coronary
heart disease complicated with carotid artery atherosclerotic plaque which were treated in our hospital fromJune 2012 to December 2014
were selected as the research object, and were divided into two groups according to the random number table method, 42 cases in each
group. Patients in the control group were given aspirin, statins and other conventional drug treatment, while the experimental group was
added with Compound Danshen Dropping Pill in the treatment and 12 weeks for a course of treatment. The changes of serum hs-CRP
level, brachial artery endothelium-dependent vasodilation street (FMD), endothelin (ET-1), nitric oxide (NO), thromboxane B2 (TXB2)
and 6 - keto - prostaglandin Fla (6-Keto-PGF-la) before and after treatment were observed and compared between two groups of patients.Results:After 1 courses of treatment, the serumlevel of hs-CRP in both groups were significantly decreased (P<0.05), and the patients in
the experimental group were significantly lower than the control group (P<0.05). The levels of 6-Keto-PGF-la, NO and FMD in the control
group were higher than those before treatment (P>0.05). The experimental group was significantly higher than those in the control
group (P<0.05 or P<0.01). The levels of ET-1 and TXB2 in the control group were significantly lower than before treatment, but were not
significantly (P<0.05), the levels of ET-1 and TXB2 of the experimental group were significantly lower than before treatment (P<0.05 or
P<0.01).Conclusion:Compound Danshen dripping pills could significantly reduce the serum CRP levels and improve the vascular endothelial
function of patients with coronary heart disease and carotid atherosclerosis. |
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