| 游碧蓉 陈昶 田新玮 王贵鹏 薛冰 李玲玲.D- 二聚体、血流变学指标对结缔组织病患者诊疗价值研究[J].现代生物医学进展英文版,2016,16(15):2902-2904. |
| D- 二聚体、血流变学指标对结缔组织病患者诊疗价值研究 |
| The Value of D-dimer and Changes of Blood Rheology Index in theDiagnosis of Connective Tissue Disease |
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| DOI： |
| 中文关键词: 结缔组织病合并多器官损害 D-二聚体 血流变 |
| 英文关键词: Connective tissue disease with multiple organ damage D-dimer Blood flow changes |
| 基金项目:新疆自治区科技项目计划基金资助（201391348） |
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| 中文摘要: |
| 目的：探讨分析结缔组织病合并多器官损害患者D-二聚体（DD）、血流变学指标（血浆纤维蛋白原/ 血浆纤维蛋白降解产物
FDP、全血黏度、血浆黏度）水平及指标变化对结缔组织病合并多器官损害患者病情活动期的诊疗价值。方法：本研究共纳入120
例患者，其中活动组患者60例，病情缓解组患者60例，分别测定二组患者DD、血流变学指标水平，并采用t 检验、灵敏度与特异
度进行统计学分析与描述。结果：与缓解组比较，活动组DD、纤维蛋白降解产物（FDP）、全血黏度、血浆黏度、酌球蛋白、补体C4、
ESR 均具有统计学差异（P＜0.01），补体C3 组间差异也具有统计学意义（P＜0.05）。各指标对于疾病活动性诊断的准确性，其
DD>FDP>补体C3、C4 > |
| 英文摘要: |
| Objective:To analyze the levels of D-dimer (DD), blood rheology indexes (fibrinogen/ plasma fibrin degradation products
(FDP), whole blood viscosity (1/S) and plasma viscosity), and to explore the value of D-dimer and changes of blood rheology indexes
in the diagnosis of connective tissue disease with multiple organ damage.Methods:The study included 120 patients, 60 cases in active
group, 60 cases in remission group. The levels of DD, FDP, whole blood viscosity and plasma viscosity were detected, and were statistically
analyzed using t-test. The sensitivity and specificity were also analyzed.Results:Compared with the remission group, the levels of
DD, FDP, whole blood viscosity, plasma viscosity, r-globulin, complement C4 and ESR all had statistically significant differences in
the active group (P<0.01), so was the complement C3 (P<0.05). The accuracy of each indicator for the diagnosis of disease activity was
DD> FDP> Complement C3, C4> r-globulin> blood rheology index > whole blood viscosity > ESR.Conclusion:The fibrinolysis level
and microcirculation were closely related to the disease activity of multi-organ damaged patients with connective tissue disease. |
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