| 周婧婷 许晶晶 霍剑锋 戴启宇 赵俊楠.肺癌患者血清CEA，CA19-9，CA125 及CA153 围手术期动态监测的临床
意义[J].现代生物医学进展英文版,2016,16(15):2896-2898. |
| 肺癌患者血清CEA，CA19-9，CA125 及CA153 围手术期动态监测的临床
意义 |
| Clinical Significance of Monitoring Preoperative CEA, CA19-9, CA125 andCA153 in Patients with Lung Cancer |
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| DOI： |
| 中文关键词: 肺癌 CEA CA19-9 CA125 CA153 |
| 英文关键词: Lung cancer CEA CA19-9 CA125 CA153 |
| 基金项目:国家自然科学基金青年基金项目（81309665） |
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| 中文摘要: |
| 目的：探讨动态监测肺癌患者围手术期血清CEA、CA19-9、CA125及CA153水平变化的临床意义。方法：随机选取2014 年
5 月至2015 年5 月收治的肺癌患者58例为研究对象，另选取同期在我院接受体检的健康人群15 例为对照组。分别测定肺癌患
者手术前及术后1 天、1 周、1 个月、3 个月的血清CEA、CA19-9、CA125、CA153 水平，并与对照组的上述各血清肿瘤标志物进行
比较。结果：肺癌患者术前空腹血清CEA、CA19-9、CA125、CA153 水平明显高于对照组，差异具有统计学意义（P＜0.01）。肺癌患
者术后1 天、1 周、1 个月及3 个月的血清CEA、CA19-9、CA125、CA153水平明显低于术前，差异具有统计学意义（P＜ 0.05）。肺癌
患者术后1 个月的平均空腹血清CEA、CA19-9、CA125、CA153 水平高于术后3 个月平均水平，但差异不具有统计学意义（P＞
0.05）。结论：对肺癌患者的血清CEA、CA19-9、CA125、CA153 水平进行围手术期动态监测有助于评估手术治疗效果。 |
| 英文摘要: |
| Objective:To explore the value of monitoring the dynamic changes of perioperative serum levels of CEA, CA19-9,
CA125 and CA153 in patients with lung cancer.Methods:58 patients with lung cancer who were treated in our hospital from May 2014
to May 2015 were selected as the cancer group, and another 15 healthy people who had taken the check-up in our hospital were chosen
to be the control group. The serum levels of CA19-9, CA125, CA153 and CEA were measured before and 1 days, days, 1 weeks, 1
months, 3 months after operation, and compared with those of the control group.Results:The levels of CEA, CA19-9, CA125 and
CA153 in patients with lung cancer were significantly higher than those of the control group (P<0.01). The levels of serumCEA, CA125,
CA19-9 and CA153 were significantly lower than the 1 day, 7 days, 1 week, 1 month and 3 months after surgery, and the difference was
statistically significant (P<0.05). The average serumof CEA, CA19-9, CA153 and CA125 levels in patients with lung cancer were higher
in 3 months after operation than before surgery, but the difference was not statistically significant (P>0.05).Conclusion:Dynamic monitoring
of perioperative CEA, CA19-9, CA125 and CA153 in patients with lung cancer can indicate the clinical effects. |
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