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目的：评估高尿酸血症(Hyperuricemia, HUA)与动脉硬化(Arteriosclerosis, AS)的关系。方法：收集841 例通过检测心- 踝血管指数(Cardio-ankle vascular index, CAVI)诊断为动脉硬化的人群作为研究组，采取成套配对1:1 病例对照方案，收集非动脉硬化人群(CAVI＜9.0)，841 例为对照组，分析两组人群中血尿酸、血脂、空腹血糖、血压、体质指数及腰围的差异性。校正混杂因素后比较两组人群中血尿酸的差异，研究高尿酸血症与动脉硬化的相关性。结果：研究组与对照组间人群的腰围、收缩压、空腹血糖、血清总胆固醇、三酰甘油、高密度脂蛋白胆固醇及血尿酸存在统计学差异(P=0.000)，校正混杂因素后，血尿酸是动脉硬化的危险因素 (OR=1.003 Cl95 %1.002-1.004 P=0.000)。高尿酸血症在两组间的优势比为1.657(P=0.000 Cl95 %1.311-2.101)。结论：除血脂、血糖、血压及腰围等因素外，高尿酸血症同动脉硬化关系密切。

英文摘要:

Objective:To explore the association of hyperuricemia with atherosclerosis.Methods:The study enrolled 841 participants with arteriosclerosis(CAVI≥ 9.0) diagnosed by Cardio-ankle Vascular Index as the Research Group(G1) and 841 cases without arteriosclerosis( CAVI < 9.0) as the Control Group(G2). The differences in clinical parameters including Systolic Blood Pressure, Diastolic Blood Pressure, Total Cholesterol, Triglyceride, High Density Lipoprotein Cholesterol, Low Density Lipoprotein Cholesterol, Body Mass Index, Waist Circumference, Fasting Plasma Glucose and Serum Uric Acid were compared between the two groups.Results:There were significant differences in Waist Circumference, Systolic Blood Pressure, Diastolic Blood Pressure, Triglyceride, High Density Lipoprotein Cholesterol, Fasting Plasma Glucose and Serum Uric Acid between the Research Group and the Control Group (P=0.000). Serum Uric Acid is a risk factor for arteriosclerosis (OR=1.003 Cl95 % 1.002-1.004 P=0.000) after further adjusting for confounding factors. The Odds Ratio of hyperuricemia between the Research Group and the Control Group is 1.657 (P=0.000 Cl95 % 1.311-2.101).Conclusion:Hyperuricemia is closely related to arteriosclerosis.

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