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目的：探讨Fisher 判别对肺磨玻璃结节(ground-glass opacity，GGO)CT 鉴别诊断的价值。方法：回顾性分析苏州大学附属第一医院2009 年8 月～2015 年8 月收治的经病理证实的GGO 患者80例，对结节主要CT 形态特征进行评价，采用卡方检验行单因素分析，以两组之间有统计学意义的CT 征象为判别指标行fisher判别，采取刀切法估计误判率。结果：80 例GGO 分为两组，良性者29 例，恶性者51 例，单因素分析显示良恶性GGO结节形态、分叶征、毛刺征、胸膜凹陷征、空泡征以及病灶界面比较差异有统计学意义，以其为判别指标行Fisher 判别，所得Fisher 判别公式为Z=-1.864X1+1.434X2+2.091X3+1.154X4+0.492X5+0.996X6+ 0.677X7-1.008，误判率为13.7 %，敏感性达91.7 %，特异性78 %，准确率86.3 %。结论：Fisher判别模型诊断GGO 具有较高的敏感性、特异性、准确性及临床实用价值。

英文摘要:

Objective:To assess the differential diagnostic value of fisher discriminant in analyzing ground-glass opacity(GGO) by spiral CT scanning.Methods:A retrospective study was conducted in 80 cases of GGO, got definite pathological diagnosis, from August 2009 to August 2015 in the First Affiliated Hospital of Soochow University. The CT morphological features were evaluated by x2-test and fisher discriminant was applied to the parameters with significant difference. Jackknife was used for estimating the rate of miscarriage justice.Results:80 cases with GGO were divided into 2 groups: benign group (n=29), malignant (n=51). Single factor analysis showed that there were significant differences in nodules form, lobulated sign, spicule sign, pleural indentation sign, bronchus encapsulated air sign, nodule interface between benign and malignant lesions. The formula of fisher discriminant was Z= -1.864X1+1.434X2+2.091X3+ 1.154X4+0.492X5+0.996X6+0.677X7-1.008, the rate of miscarriage of justice was 13.7 %, the sensitivity and specificity were 91.7 % and 78 % respectively, the accuracy was 86.3 %.Conclusion:Fisher discriminant mode could effectively make differential diagnosis of GGO, which had high sensitivity, specificity, accuracy and value in clinical experience.

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