| 刘爽 马荣△ 贺云龙 刘禹池 孙丽美.宫颈鳞状细胞癌中ADAM17 的表达及其临床意义[J].现代生物医学进展英文版,2016,16(15):2868-2871. |
| 宫颈鳞状细胞癌中ADAM17 的表达及其临床意义 |
| Expression and Clinicopathological Significance of ADAM17 in CervicalSquamous Cell Carcinoma |
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| DOI： |
| 中文关键词: 去整合素-金属蛋白酶17 宫颈鳞状细胞癌 免疫组化 蛋白印迹 |
| 英文关键词: ADAM17 Squamous cell Carcinoma of Cervix Immunohistochemistry Western blot |
| 基金项目:黑龙江省教育厅科学技术研究项目（12521235） |
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| 中文摘要: |
| 目的：探讨去整合素-金属蛋白酶17（ADAM17）在宫颈鳞状细胞癌中的表达及其临床病理意义。方法：运用免疫组织化学
法分别检测正常宫颈上皮、宫颈鳞状细胞癌及宫颈上皮内瘤样变组织中ADAM17 的表达，并分析其与宫颈癌临床分期及淋巴结
转移的相关性。结果：ADAM17 在正常宫颈上皮组织切片中无明显表达，在宫颈上皮内瘤样变组织中少部分表达，呈浅黄色，在宫
颈鳞状细胞癌中癌细胞大量表达，ADAM17表达呈棕褐色，数量较多且浓染。不同临床分期的宫颈鳞状细胞癌组织中ADAM17
的阳性表达率比较存在显著统计学差异（P<0.05），且随临床分期的上升，ADAM17的表达逐渐升高；有淋巴结转移的宫颈鳞状细
胞癌组织中ADAM17 的阳性表达率显著高于无淋巴结转移的宫颈鳞状细胞癌组织，差异具有统计学意义（P<0.05）。结论：
ADAM17 蛋白在宫颈鳞状细胞癌组织中呈异常高表达，且与宫颈鳞状细胞癌的临床分期和淋巴结转移密切相关，通过检测
ADAM17 蛋白的表达可能有助于宫颈鳞状细胞癌的诊断、治疗和预后预测。 |
| 英文摘要: |
| Objective:To investigate the expression of adisintegrin and metalloproteinase 17 (ADAM17) in cervical squamous
cell carcinoma and its clinicopathological significance.Methods:The expression of ADAM17 in normal epithelium, cervical intraepithelial
neoplasia and cervical squamous cell carcinoma was respectively detected by Western Blot immunoblotting, Immunohistochemical
(SP) method, And the relationship between the expression of ADAM17 and the clinical stage of cervical cancer and lymph node metastasis
was analyzed.Results:There was no obvious ADAM17 expression in normal cervical epithelium tissues, and a few expression in
cervical intraepithelial neoplasia with light yellow staining in the cytoplasm, and abundant ADAM17 expression in cervical squamous
cell carcinoma with strong brown dying in the cytoplasm. The positive expression rate of ADAM17 in each group were significantly different
(P<0.05), the expression of ADAM17 was gradually increased with the severity of clinical stage. The positive rate of ADAM17 expression
was significantly higher in cervical squamous cell carcinoma with lymph node metastasis than those without lymph node metastasis,
and the difference was statistically significant (P<0.05).Conclusion:ADAM17 is highly expressed in cervical squamous cell carcinoma,
and its positive expression is closely associated with clinical staging and lymph node metastasis, indicating thatADAM17 can be
used as a marker of clinical diagnosis and prognosis of cervical squamous cell carcinoma. |
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