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目的：探讨不同天数姜黄素灌胃对顺铂所致小鼠胃排空障碍的作用及其是否通过减轻氧化损伤发挥作用。方法：健康成年昆明种小鼠，随机分为对照组、顺铂组、姜黄素组和顺铂+姜黄素灌胃1 天、5 天、10 天、15 天、20 天和30 天组，每组8 只。用药结束后24 小时测量胃残留率并取胃组织检测MDA和SOD 含量。结果：注射顺铂后，各组小鼠体重明显减轻，姜黄素灌胃10~30 天可明显减轻顺铂导致的体重减少(P<0.05)；注射顺铂后各组胃残留率升高(P<0.05)，而姜黄素预先灌胃10~30 天可明显减轻顺铂导致的胃残留率增高(P<0.05)，各组间治疗效应无明显差异。姜黄素灌胃1~5 天组小鼠体重和胃残留率都无显著改善。各组胃组织中MDA 和SOD含量差异无统计学意义(P>0.05)。结论：姜黄素预先灌胃10天以上可改善顺铂所致的小鼠胃排空障碍，但延长天数并不会有进一步改善；其作用可能不主要通过抗氧化途径。

英文摘要:

Objective:To investigate the effect of curcumin gavage for different days on the dysfunction of gastric emptying in mice induced by cisplatin, and to explore whether the effect of curcumin worked through antioxidant.Methods:Male mice were randomLy divided into 9 groups: Control, cisplatin, curcumin, cisplatin+curcumin 1 day, 5 days, 10 days, 15 days, 20 days and 30 days. At 24 hours after the of end of the experiment, the gastric residual rate and the content of MDA and SOD in stomach tissues were detected.Results:The body weight of mouse in each group was reduced significantly after cisplatin injection. The reduce of body weight of mice was alleviated by curcumin gavage for 10~30 days (P<0.05). The gastric residual rate of mice was increased obviously after cisplatin injection( P<0.05). Curcumin gavage for 10~30 days could decreased the gastric residual rate of mice(P<0.05), and the effects of curcumin in 10~30 days group have no obvious difference(P>0.05). There was no significant improvement in cisplatin+curcumin 1 or 5 days group (P>0.05). The contents of MDA and SOD had no obvious changes among each group(P>0.05).Conclusion:Curcumin gavage more than 10 days can ameliorate the gastric emptying disorder of mice induced by cisplatin, and more days administrating of curcumin does not produce more effects. The antioxidant effect may not play the major role in this process.

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