| 孙爱丽 郁向静 孙宇 张伟华.糖尿病血管平滑肌细胞增殖与线粒体关系的研究进展[J].现代生物医学进展英文版,2016,16(14):2783-2785. |
| 糖尿病血管平滑肌细胞增殖与线粒体关系的研究进展 |
| The Research Progress between the Proliferation of Diabetes VascularSmooth Muscle Cell and Mitochondria |
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| DOI： |
| 中文关键词: 糖尿病 血管平滑肌细胞 线粒体 ROS |
| 英文关键词: Diabetes Vascular smooth muscle cell Mitochondria Reactive Oxygen Species |
| 基金项目:国家自然科学基金项目（81370421） |
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| 中文摘要: |
| 糖尿病（diabetes mellitus，DM）是严重危害人类健康的全身性代谢疾病，常发生血液流变学、微循环和细胞代谢的紊乱，导致
缺血、缺氧和组织水肿，进而引起血管和神经病变。血管病变常常是糖尿病病人致死、致残的主要原因。血管平滑肌细胞的增殖及
表型改变是糖尿病引发动脉粥样硬化性疾病的显著特征，而线粒体在血管平滑肌细胞的增殖过程中起重要作用。因此，探讨糖尿
病血管平滑肌细胞与线粒体的关系及机制为糖尿病血管性疾病的治疗提供重要的理论基础，有利于基础研究向临床试用药物研
究的转化。 |
| 英文摘要: |
| Diabetes mellitus (DM) is a systemic metabolic disease which seriously impairs human’s health. Patients with DM
frequently represents disorders of hemorheology, microcirculation and cell metabolism which could lead to ischemia, hypoxia and tissue
edema, further resulting in vascular and nervous abnormalities. Vasculopathy is often regarded as the main cause for the lethality and
disability of diabetic patients. Proliferation of vascular smooth muscle cells and phenotypic changes are main characteristics of
atherosclerosis disease caused by diabetes. Meanwhile, mitochondria play an important role in the process of proliferation. Therefore, the
exploration of the relationship between mitochondria and the vascular smooth muscle cell in diabetes mellitus can provide an important
theoretical basis for the treatment of diabetic vascular disease, which is beneficial for the transformation from fundamental research to
clinical drug research. |
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