| 付爽 高旋 杨雪松 张莹雪 刘广旭.扶他林对类风湿性关节炎患者血清VEGF及TNF-alpha水平的影响及其临床疗效[J].现代生物医学进展英文版,2016,16(14):2744-2747. |
| 扶他林对类风湿性关节炎患者血清VEGF及TNF-alpha水平的影响及其临床疗效 |
| Effects of Voltaren on the Changes of VEGF and TNF-alpha in Patients withRheumatoid Arthritis and its Clinical Curative Effect |
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| DOI： |
| 中文关键词: 扶他林 类风湿性关节炎 VEGF TNF-alpha 临床疗效 |
| 英文关键词: Voltaren Rheumatoid arthritis VEGF TNF-alpha Clinical efficacy |
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| 中文摘要: |
| 目的：探究扶他林对类风湿性关节炎患者VEGF, TNF-alpha及临床疗效的影响。方法：收集于我院就诊的类风湿性关节炎86
例，根据治疗方法不同分为对照组和治疗组，其中治疗组44 例服用扶他林肠溶片治疗，对照组42 例服用布洛芬片治疗。观察并
比较两组患者血清VEGF及TNF-alpha水平的变化情况、关节功能评分、血沉情况以及临床疗效。结果：与对照组比较，治疗组患者的
临床总有效率较高，晨僵时间、关节疼痛数、关节肿胀数、关节功能分级、血沉比以及血清VEGF及TNF-琢水平较低，差异均具有
统计学意义（P＜0.05）。结论：扶他林对类风湿性关节炎的临床治疗效果显著，能够降低患者血清VEGF及TNF-alpha水平，改善炎症
反应，适宜临床推广应用。 |
| 英文摘要: |
| Objective:To investigate the effect of voltaren on the changes of VEGF and TNF-alpha in patients with rheumatoid
arthritis and its clinical curative effect.Methods:86 patients with rheumatoid arthritis who were treated in our hospital were selected and
divided into the control group and the experiment group. 44 cases in the experiment group were treated with voltaren, while another 42
cases in the control group were treated with Nuprin Tablets. Then the changes of VEGF and TNF-alpha, the joint function score, the
erythrocyte sedimentation rate and the clinical curative effect in the two groups were observed and compared before and after the
treatment.Results:Compared with the control group, the total clinical efficiency were higher, the The time of morning stiffness, joint
pain, joint swelling, joint function classification and ESR, and the levels of VEGF and TNF-alpha were lower, and the differences were
statistically significant (P<0.05).Conclusion:Voltaren has remarkable clinical effects on the treatment of rheumatoid arthritis, which can
reduce the levels of serumVEGF and TNF-琢, and improve the inflammatory reaction, and it is worthy of clinical application. |
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