| 常久魁 刘晓荣 郑建辉 周晋 刘维田 徐雅彪 张国栋.急性脑出血患者颈动脉斑块与血清hs CRP 及HbAlc的相关性研究[J].现代生物医学进展英文版,2016,16(13):2530-2532. |
| 急性脑出血患者颈动脉斑块与血清hs CRP 及HbAlc的相关性研究 |
| Acute Cerebral Hemorrhage: Correlation of Serumhs CRP, HbAlc and Carotid Atherosclerosis Plaque |
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| DOI： |
| 中文关键词: 急性脑出血 血清超敏C 反应蛋白 糖化血红蛋白 |
| 英文关键词: Acute cerebral hemorrhage High sensitivity C-reactive protein(hs-CRP) Glycated haemoglobin(HbAlc) |
| 基金项目: |
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| 中文摘要: |
| 目的：探究急性脑出血患者颈动脉斑块与血清超敏C 反应蛋白（hs-CRP）及糖化血红蛋白（HbAlc）的相关性。方法：随机选取
我院2013 年5 月至2015 年1 月脑科收治的急性脑出血患者84 例，根据颈动脉粥样硬化标准将所有患者分为单纯脑出血组
（n=25）、轻度粥样硬化组（n=34）和重度粥样硬化组（n=25）三组，另选取同期我院健康体检者50 人（对照组）。对比分析四组颈总
动脉膜厚度（IMT）空腹血糖（FPG）、三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、hs-CRP 与HbAlc
水平，分析急性脑出血患者颈动脉斑块的危险因素。结果：四组的IMT、TC、TG、HDL、LDL、hs-CRP 和HbAlc 水平差异均具有统
计学意义（P<0.05），其中hs-CRP 和HbAlc 水平在单纯脑出血组< 轻度粥样硬化组< 重度粥样硬化组（P<0.05）；IMT 与hs-CRP
和HbAlc 均呈现正相关（r=0.388、0.420，P<0.05）；IMT、hs-CRP 和HbAlc 均为颈动脉粥样硬化的危险因素（OR=3.065、1.978、
1.647，P<0.05）。结论：急性脑出血患者体内hs-CRP 及HbAlc 水平是颈动脉斑块形成的危险因素。 |
| 英文摘要: |
| Objective:To explore the correlation of serum high sensitivity C-reactive protein (hs-CRP), glycated haemoglobin
(HbAlc) and carotid atherosclerosis plaque in patients with acute cerebral hemorrhage.Methods:A total of 84 patients with acute cerebral
hemorrhage, who were admitted to People's Hospital of Fengrun District fromMay 2013 to January 2015, were selected and randomly divided
into acute cerebral hemorrhage group (n=25), mild atherosclerosis group (n=34) and severe atherosclerosis group (n=25), and 50
healthy people were chosen as control group in the same period. Then the intima-media thickness(IMT), fasting plasma glucose(FPG), triacylglyceride(
TG), total cholesterol(TC), low density lipoprotein(LDL), high density lipoprotein(HDL), hs-CRP and HbAlc of the four
groups were compared, and the risk factors of carotid atherosclerosis plaque were analyzed.Results:There were statistical differences in
the levels of IMT, TC, TG, HDL, LDL, hs-CRP and HbAlc between the four groups (P<0.05). IMT was positively correlated with
hs-CRP and HbAlc (r=0.388,0.420, P<0.05). IMT, hs-CRP and HbAlc were the risk factors of carotid atherosclerosis plaque(OR=3.065,
1.97, 1.647, P<0.05).Conclusion:hs-CRP and HbAlc in patients with acute cerebral hemorrhage are the risk factors of formation of
carotid atherosclerosis plaque. |
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