| 杨嘉琳 池凯仪 龙振鸿 徐文婷 徐仲.限制性液体复苏对失血性休克复苏患者血浆TNF-alpha、IL-6 水平的影响[J].现代生物医学进展英文版,2016,16(13):2513-2515. |
| 限制性液体复苏对失血性休克复苏患者血浆TNF-alpha、IL-6 水平的影响 |
| Effect of Limited Fluid Resuscitation on Plasma TNF-alpha and IL-6 Levels inPatients with Hemorrhagic Shock Resuscitation |
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| DOI： |
| 中文关键词: 限制性液体复苏 失血性休克复苏 TNF-alpha IL-6 |
| 英文关键词: Limited fluid resuscitation Hemorrhagic shock resuscitation Tumor necrosis factor-alpha Interleukin-6 |
| 基金项目:广州市医药卫生科技项目（20151A010105） |
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| 中文摘要: |
| 目的：探究限制性液体复苏对失血性休克复苏患者血浆肿瘤坏死因子（TNF-alpha）、白细胞介素-6（IL-6）水平的影响，为临床治
疗失血性休克选择液体复苏方式提供依据。方法：选择2010 年1 月~2015 年6 月期间，我院收治出血性休克患者63例为研究对
象；采用随机数字法将其分为观察组（32 例）和对照组（31 例），观察组患者给予限制性液体复苏，对照组患者给予传统充分复苏；
观察并比较两组患者治疗前后血浆TNF-alpha、IL-6 水平的变化。结果：观察组患者给予复苏液体的输入量为（1.95± 0.35）L，对照组
患者给予输液量为（3.61± 0.56）L，观察组患者给予的复苏液输入量显著低于对照组，差异具有统计学意义（P<0.05）；治疗前两组
患者血浆TNF-alpha及IL-6 水平不存在显著差异（P>0.05）；治疗后两组患者血浆TNF-alpha及IL-6 水平均显著上升，且观察组患者血浆
TNF-alpha及IL-6水平均显著低于对照组，差异具有统计学意义（P<0.05）。结论：限制性液体复苏能够明显降低失血性休克患者的出
血量，稳定机体血流动力学，保证机体重要脏器的血流灌注，有利于改善患者血浆TNF-琢和IL-6 水平，提高治疗效果，改善预后。 |
| 英文摘要: |
| Objective:To explore the effect of limited fluid resuscitation on plasma tumor necrosis factor-alpha(TNF-alpha) and interleukin-
6(IL-6) levels in patients with hemorrhagic shock resuscitation, to provide the basis for clinical treatment of hemorrhagic shock in
the choice of liquid recovery.Methods:Selected 63 cases of patients with hemorrhagic shock in our hospital from January 2010 to June
2015 as the research object; Which were divided into observation group(32 patients) and control group (31 patients) by random number
table method, the patients in observation group was given a limited fluid resuscitation, and the patients in control group received traditional
full recovery; Observed and compared the changes of plasma TNF-alpha and IL-6 levels in two groups before and after treatment.Results:The input of recovery fluid of the patients in the observation group was(1.95 + 0.35) L, which was significant higher than (3.61 + 0.56)L
of control group, the difference was statistically significant(P<0.05); There was no significant difference in plasma TNF-alpha and IL-6 levels
between the two groups before treatment(P>0.05); The plasma levels of TNF-alpha and IL-6 in the two groups were significantly in- creased,
and plasma TNF-alpha and IL-6 levels in the observation group were significantly lower than those in the control group after treat- ment, the
difference was statistically significant(P<0.05).Conclusion:Limited fluid resuscitation can significantly reduce the amount of bleeding in
patients with hemorrhagic shock, stabilize the blood flow dynamics and ensure the blood flow of the important organs of the body; It is
beneficial to improve the level of plasma IL-6 and TNF-alpha in patients,improve the therapeutic effect and improve prognosis. |
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