| 邓显峰 朱峰 陈伟 李国保 许玲.2 型糖尿病与干眼症的相关性研究及其危险因素分析[J].现代生物医学进展英文版,2016,16(13):2503-2506. |
| 2 型糖尿病与干眼症的相关性研究及其危险因素分析 |
| Research on the Relation between Type 2 Diabetes Mellitus and Dry EyeDisease and Analysis on the Risk Factors |
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| DOI： |
| 中文关键词: 2型糖尿病 干眼症 危险因素 回归分析 |
| 英文关键词: Type 2 diabetes Dry eyes Risk factors Regression analysis |
| 基金项目:湖北省卫生厅科研基金项目（WJ2009108） |
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| 中文摘要: |
| 目的：探讨2 型糖尿病和干眼症的关系并分析2 型糖尿病发生干眼症的危险因素。方法：纳入2 型糖尿病患者220 例为观
察组和健康人群50 例为对照组，采集所有研究对象眼表失衡指数(OSDI)、泪膜破裂时间(TBUT)、泪液分泌试验(SIt)，以及观察组
性别、年龄、糖尿病病程、血糖、HbA1c、HOMA-IR、血清CRP，对比分析两组患者干眼症发病率及干眼症症状，采用多因素Logistic
回归分析影响2 型糖尿病发生干眼症的危险因素。结果：对照组干眼症发病率(9/100，9.00%)明显低于观察组(108/440 眼,24.52%)
(P<0.05)。观察组OSDI评分明显高于对照组(P<0.05)。观察组TBUT、SIt 明显小于对照组，两组间差异有统计学意义(P<0.05)。性
别、年龄、糖尿病病程、OSDI、TBUT、SIt、HbA1c 和2 型糖尿病患者发生干眼症具有一定的相关性(P<0.05)。年龄、糖尿病病程、
TBUT、HbA1c 是2 型糖尿病患者发生干眼症的危险因素(B>0, OR>1)。结论：2型糖尿病和干眼症具有一定的相关性，糖尿病患者
年龄、糖尿病病程、血糖控制水平是2 型糖尿病发生干眼症的独立危险因素。 |
| 英文摘要: |
| Objective:To research the relationship between type 2 diabetes and dry eyes and to analyze the risk factors of type 2
diabetes occurring with dry eyes.Methods:A total of the 220 patients with type 2 diabetes were included as the observation group and 50
cases of healthy people were chosen as the control group. Ocular surface disorder index (OSDI), tear break up time (TBUT), Schirmer I
test (Sit) were collected fromall subjects. The gender, age, duration of diabetes, blood glucose, HbA1c, HOMA-IR and serumCRP were
detected in observation group. Compare the symptoms and morbidity of dry eyes between two groups. Use the multiariable Logistic regression
to analyze the factors influencing type 2 diabetes patients with dry eyes.Results:The incidence of dry eyes was 9.00%(9/100) in
control group, significantly lower than in observation group (108/440, 24.52%) (P<0.05). OSDI score in observation group was obviously
higher than in control group (P<0.05). TBUT and SIt in observation group were obviously lower than in control group, and the differences
between two groups has statistically significance (P<0.05). The gender, age, duration of diabetes, OSDI, TBUT, SIt, HbA1c of type
2 diabetes patients has certain correlation with occurrence of dry eyes (P<0.05) through single factor analysis. The blood glucose levels,
HOMA-IR, serum CRP has no significant correlation with dry eyes (P>0.05). The age, duration of diabetes, TBUT, HbA1c in type 2 diabetes
patients were independent factors for occurrence of dry eyes by logistic regression analysis (B>0, OR>1).Conclusion:Type 2 diabetes
has certain relevance with dry eyes. The age of diabetic patients, duration of diabetes, blood sugar control levels are independent
risk factors for type 2 diabetes occurring dry eyes. |
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