| 宋玉莲 白若岑 刘铁峰 柴伟 韩波 邓玉玲.HCY、CRP、Fib、WBC 水平在冠心病诊断中的临床价值[J].现代生物医学进展英文版,2016,16(13):2493-2495. |
| HCY、CRP、Fib、WBC 水平在冠心病诊断中的临床价值 |
| The Clinical Value of Homocysteine, C-reactive Protein, Fibrinogen andWhite Blood Cell Count in Diagnosis of Coronary Disease |
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| DOI： |
| 中文关键词: 冠心病 BMI 同型半胱氨酸 C 反应蛋白 纤维蛋白原 |
| 英文关键词: Coronary disease BMI Homocysteine C-reactive protein Fibrinogen |
| 基金项目:卫生部医药卫生科技发展项目（W2013GJ09） |
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| 中文摘要: |
| 目的：探讨血清同型半胱氨酸（HCY）、C 反应蛋白、纤维蛋白原（Fib）、白细胞(WBC)与冠心病（CHD）病变程度的相关性和作
为检测指标的敏感性；检测BMI 是否为CHD 的独立风险因子。方法：测定102 例不同类型冠心病患者和33 例健康的HCY、
CRP、Fib、WBC的水平，比较AMI.UAP.SAP 组和对照组间各项指标的差异。结果：BMI>24 和BMI<24 两组中AMI、UAP、SPA 和
Control的构成比的差别，结果显示男性患者中两组构成有明显差异（P=0.011）；女性患者中两组构成没有明显差异（P=0.28）。各
组的HCY、CRP、Fib 和WBC 的水平为：AMI组大于UAP 组大于SAP 组大于对照组，AMI组与UAP 组相比，差异有统计学意义
（均为P<0.01），UAP 组与SAP 组相比，差异有统计学意义（P<0.05, P<0.01）。CRP和WBC的诊断价值较好，HCY和Fib的诊断价
值中等。结论：同型半胱氨酸、C 反应蛋白、纤维蛋白原和白细胞水平变化与冠心病的发生、发展密切相关，它们的四个指标可作为
区别冠心病类型和评价其病变严重程度的辅助性指标。 |
| 英文摘要: |
| Objective:To research the correlation of homocysteine (HCY), C-reactive protein(CRP), fibrinogen (FIB) and white
blood cell count (WBC) with pathological change degree of coronary heart disease (CHD) and the sensitivity as indictors of CHD, and to
investigate whether BMI is the independent risk factor of CHD.Methods:The levels of HCY, CRP, Fib and WBC were measured and
compared in 102 cases of CHD and 33 cases of healthy controls (healthy control group).Results:BMI risk prediction values in male patients
(OR) was3 (P=0.0453), and the results showed BMI> 24 was an independent risk factor for the male to have MI. The BMI risk
prediction (OR) was 0.61 for female patients (P=0.4274), and the results showed a BMI> 24 was not a risk factor for the female to have
MI disease. It is showed that male patients between BMI> 24 group and BMI <24 group had differences (P=0.011) in constituent ratio of
AMI, UAP, SPA and Control, while female patients in the two groups had no significant difference (P=0.28). Plasma concentrations of
HCY, CRP, Fib and WBC were the highest in AMI group, followed by those in UAP group, SAP group and healthy control group. There
were statistical differences in the above parameters between AMI group and UAP group (all P<0.01), and so were between UAP group
and SAP group (P<0.05, P<0.01). There was no significant difference between UAP group and healthy control group (P>0.05). ROC
curve of HCY was 0.84, ROC curve of CRP was 1, ROC curve of Fib was 0.75, ROC curve of WBC was 0.96. The results showed that
the diagnostic value of CRP and WBC was better than diagnostic value of HCY and Fib.Conclusion:The changes of HCY, CRP, Fib and
WBC were closely associated with the occurrence and development of coronary heart disease. The above four parameters can be used as
adjuvant indicators in differentiating types of CHD and evaluating severity of disease. |
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