| 眭鸿颖 史彩霞 江宁 李虎成 兰菁.高危型HPV 感染对宫颈病变组织IFN-r、IL-10表达的影响[J].现代生物医学进展英文版,2016,16(13):2484-2486. |
| 高危型HPV 感染对宫颈病变组织IFN-r、IL-10表达的影响 |
| Effect of High Risk HPV Infection on Expression of IFN-r and IL-10 inCervical Lesions |
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| DOI： |
| 中文关键词: 人乳头状瘤病毒 干扰素-r 白细胞介素-10 |
| 英文关键词: The expression of IFN-ris gradually reduced along with the increase of cervical lesions, HPV16 and HPV18, while the expression of
IL-10 is gradually increased. |
| 基金项目:湖南省科学技术厅科技计划项目（2012SK3254） |
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| 中文摘要: |
| 目的：探讨高危型人乳头瘤病毒（HPV）感染对宫颈病变组织干扰素-r(IFN-r)、白细胞介素-10(IL-10)的影响。方法：收集我
院2013 年1 月到2015 年1 月妇科门诊行宫颈活检患者150 例，根据病理检查结果，将患者分为观察组（宫颈癌33 例、CINⅠ期
26 例、CINⅡ期28 例、CINⅢ期23 例）110 例，对照组（慢性宫颈炎患者）40 例。提取两组患者宫颈组织标本，检测观察组
HPV-DNA、HPV 分型，及两组IFN-r、IL-10 蛋白及mRNA 表达，分析高危型HPV感染与宫颈病变组织IFN-r、IL-10 表达的关系。
结果：观察组HPV-DNA阳性87 例（79.1%），其中HPV16 型47 例（42.7%）、HPV18 型20 例（18.2%）感染率最高；且HPV16、18 感
染率在CINⅠ期、CINⅡ期、CINⅢ期以及宫颈癌组中的感染率差异均有统计学意义（P<0.05），Spearman相关性分析显示，HPV16、
18 与宫颈病变程度均呈现正相关关系（r=0.896，0.786；均P<0.05）。IFN-r、IL-10 表达水平在CINⅠ期、CINⅡ期、CINⅢ期、宫颈
癌、对照组表达水平差异均具有统计学意义（P<0.05），Spearman 相关性分析显示，IFN-r与宫颈病变程度呈现负相关关系（r=-0.
567，P<0.05），IL-10 呈现正相关关系（r=0.678，P<0.05）。且HPV16、HPV18 感染率与IFN-r表达呈现负相关关系（rHPV16/18=-0.
678，-0.675，均P<0.05），与IL-10 呈现正相关关系（rHPV16/18=0.582，0.778，均P<0.05）。结论：IFN-r表达随着宫颈病变加重或者
HPV16、HPV18 感染率升高逐渐降低，IL-10 则逐渐升高。 |
| 英文摘要: |
| Objective:To investigate the effect of high risk HPV infection on the expression of IFN-r and IL-10 in cervical lesions.Methods:A total of 150 patients, who accepted cervical biopsy in gynecological clinic of Hunan Tumor Hospital from January
2013 to January 2015,were collected and divided into observation group (n=110 : 33 cases of cervical cancer, 26 cases in CINI stage, 28
cases in CINII stage,23 cases in CINIII stage) and control group (n= 40 cases of chronic cervicitis patients) by pathological examination
results. The cervical tissue specimens of patients in the two groups were extracted; the HPV-DNA,HPV typing and the expression of of
IFN-,IL-10 protein and mRNA in the two groups were detected; the correlation of high risk HPV infection with the expression of IFN-r
and IL-10 was analyzed.Results:87 patients (79.1%) were HPV-DNA positive in the observation group, among which the infection rates
of 47 cases of HPV16 type (42.7%) and 20 cases of HPV18 type (18.2%) were the highest; the differences of infection rates of HPV16
and18 in CINI, CINII, CINIII stages and cervical cancer group were statistically significant (P<0.05), Spearman correlation analysis
showed that HPV16 and 18 were positively correlated with cervical lesions degree (r=0.896, 0.786; P<0.05). The expression levels of
IFN-rand IL-10 in CINI stage, CINII stage, CINIII stage, cervical cancer and the control group were statistically significant(P<0.05),
spearman correlation analysis showed that IFN-rwas negatively correlated with the cervical lesions degree (r=-0.567, P<0.05), and was
positively correlated with IL-10 (r=0.678, P<0.05). And the HPV16, HPV18 infection rates were negatively correlated with expression of
IFN-r(rHPV16/18=-0.678, -0.675, P<0.05), and were positively correlated with IL-10 (rHPV16/18=0.582, 0.778, P<0.05).Conclusion: |
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