| 徐祎骏 肖军 张洋 史占军.关节置换术后抗凝药物预防深静脉血栓及相关并发症的临床研究进展[J].现代生物医学进展英文版,2016,16(12):2376-2379. |
| 关节置换术后抗凝药物预防深静脉血栓及相关并发症的临床研究进展 |
| Clinical Research Progress of Anticoagulants for Prophylaxis of Deep VeinThrombosis and Complications after Arthroplasty |
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| DOI： |
| 中文关键词: 抗凝药 全髋关节置换术 全膝关节置换术 深静脉血栓 失血量 并发症 |
| 英文关键词: Anticoagulants Total hip arthroplasty Total knee arthroplasty Deep vein thrombosis Blood loss volume Complications |
| 基金项目:基金项目：国家自然科学基金项目（81501904）；广东省自然科学基金项目（2014A030310241） |
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| 中文摘要: |
| 抗凝药物有助于预防全髋关节置换术和全膝关节置换术后深静脉血栓形成，临床上最常使用的传统抗凝药物如低分子肝
素、华法林等可以起到很好的预防效果。目前有一类新的口服抗凝药物已经用于临床，为关节置换术后患者带来了一种更方便、
安全和有效预防血栓的治疗选择。本篇综述主要针对传统抗凝药物低分子肝素及维生素K 拮抗剂，直接凝血酶抑制剂达比加群，
以及选择性Xa 因子抑制剂利伐沙班和阿哌沙班，对迄今为止传统抗凝药物在全髋关节置换术和全膝关节置换术患者中的临床
使用经验、优缺点、以及新型口服抗凝药物最新临床用药进展进行综述，为关节置换术后患者预防深静脉血栓提供用药参考。 |
| 英文摘要: |
| Anticoagulants are useful for preventing deep vein thrombosis (DVT) after total hip arthroplasty and total knee
arthroplasty. The traditional anticoagulants commonly used in clinical practice, e.g., low molecular weight heparin (LMWH) and
warfarin, have produced favorable prophylactic effect. However, these conventional anticoagulants have various limitations. The
introduction of a new class of oral anticoagulants into clinical use presents a more convenient therapeutic option with better safety and
efficacy for thrombosis prophylaxis in patients who have undergone joint arthroplasty. This clinical review mainly addresses the
conventional anticoagulants LMWH and vitamin K antagonists, the direct thrombin inhibitor dabigatran, and the selective factor Xa
inhibitors rivaroxaban and apixaban, reviewing their clinical experience and latest advances in patients who have underwent total hip
arthroplasty or total knee arthroplasty, and to provide a reference for them. |
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