| 孙娟娟 宋晓婕 罗自娟 夏红慧 袁娟.高危型HPV筛查与TCT 联合检查在宫颈癌筛查中的临床应用[J].现代生物医学进展英文版,2016,16(12):2336-2338. |
| 高危型HPV筛查与TCT 联合检查在宫颈癌筛查中的临床应用 |
| Clinical Application of HR-HPV Combined with TCT in Screening ofCervical Cancer |
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| DOI： |
| 中文关键词: 高危人乳头瘤病毒 薄层液基细胞学 宫颈癌 病理学诊断 |
| 英文关键词: High risk-human papilloma virus Thin cytologic test Cervical cancer Pathological diagnosis |
| 基金项目: |
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| 中文摘要: |
| 目的：探究液基薄层细胞学检测（TCT）与高危人乳头瘤病毒（HR-HPV）筛查联合检查在宫颈癌（CC）筛查中的临床价值。方
法：选择2013 年4 月~2015 年4 月期间我院就诊疑似CC患者318 例为研究对象；研究对象均进行HR-HPV 筛查、TCT 检查及
阴道镜下病理活检，评价三种筛查结果的临床应用价值。结果：318 例可疑CC 患者中，病理学诊断炎症患者162 例（50.94%），宫
颈上皮内瘤样变（CIN）患者151 例（47.48%），鳞癌（SCC）患者5 例（1.57%）；HR-HPV、TCT 及HPV+TCT 联合对诊断结果与病理
诊断的符合率分别为78.30%、85.22%和99.37%；HR-HPV 与TCT 单独检测的符合率随患者病情进展呈现升高趋势（P<0.05）；
TCT、HR-HPV 检测单独进行诊断的敏感度、特异度均低于联合诊断(P<0.05)；HR-HPV 与TCT 联合检测诊断CC 的敏感度为
98.71%、特异度100%。结论：TCT 检查HR-HPV 筛查联合检查CC的敏感性、特异性及准确性高，为CC筛查的有效方式，值得在
临床应用推广。 |
| 英文摘要: |
| Objective:To explore the clinical application value of high risk-human papilloma virus (HR-HPV) combined with thin
cytologic test (TCT) in screening of patients with cervical cancer (CC).Methods:A total of 318 patients with suspected CC, who were
treated in Wuhan Commercial Staff Hospital from April 2013 to April 2015, were chosen as research subjects. All the subjects were
given HR-HPV, TCT screening,and pathologic biopsy under vaginoscopy. The clinical application value of the three screening methods
was evaluated.Results:The pathological results showed that there were 162 patients with inflammation (50.94%), 151 patients with
cervical intraepithelial neoplasia (CIN)(47.48%) and 5 patients with squamous cell carcinomas (SCC)(1.57%) among the 318 suspected
patients. The coincidence rate of HR-HPV, TCT and HPV+TCT and pathological results were 78.30%, 85.22%and 99.37%respectively.
The coincidence rate of HR-HPV and TCT screening were increased with the severity of disease (P<0.05).The sensitivity (98.71%) and
specificity (100%) of HPV+TCT were significantly higher than TCT, HR-HPV screening separately (P<0.05).Conclusion:HR-HPV
combined with TCT screening has high sensitivity, specificity and accuracy in the screening of patients with CC, which is an effective
way for CC screening and worth popularizing in clinical application. |
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