| 樊华 孙宁霞 王亮 杨洋 蒋小平 严建耀 朱红玲 陆晓兰△ 李文.夹竹桃麻素对双酚a诱导的成年雄性小鼠精子损伤作用的实验研究[J].现代生物医学进展英文版,2016,16(12):2264-2266. |
| 夹竹桃麻素对双酚a诱导的成年雄性小鼠精子损伤作用的实验研究 |
| Apocynin can Alleviate Bisphenol A-induced Sperm Damage in Adult MaleMice |
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| DOI： |
| 中文关键词: NADPH 氧化酶 夹竹桃麻素 双酚a 精子 氧化应激 |
| 英文关键词: NADPH oxidase Apocynin Biophenol a Sperm Oxidative stress |
| 基金项目:全军医学科研创新重点课题(13cxz006) |
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| 中文摘要: |
| 目的：研究NADPH 氧化酶抑制剂夹竹桃麻素（Apocynin）对双酚a（Bisphenol a, BPA）诱导的成年雄性小鼠精子损伤过程中
的作用。方法：成年雄性小鼠给以BPA 刺激，给以Apocynin（1 mg/kg/day 和10 mg/kg/day，分别处理7 day）进行治疗，观察其对
BPA 诱导的成年雄性小鼠精子损伤的作用。结果：BPA 处理组小鼠附睾精子数目和活力明显降低，血清中睾酮和黄体生成素水
平明显减少；Apocynin 治疗明显增加BPA 处理组小鼠附睾中精子数目和活力，但是对血清中睾酮和黄体生成素水平没有明显影
响。另外，BPA处理组小鼠睾丸中丙二醛（Malonaldehyde, MDA）水平明显增加；Apocynin 治疗明显抑制了BPA 处理组小鼠睾丸
中MDA 水平。结论：NADPH 氧化酶抑制剂Apocynin 减轻BPA 诱导的成年雄性小鼠精子损伤。 |
| 英文摘要: |
| Objective:To investigate the effect of treatment with apocynin (one NADPH oxidase inhibitor) against biophenol a
(BPA)-induced injury in sperms of male adult mice.Methods:Male adult mice were stimulated with BPA and simultaneously treated
with apocynin (1 mg/kg, 10 mg/kg) for 7 days. Testis and serumwere collected for biochemical analysis.Results:Exposure to BPA led to
reduced number and motility of sperms of epididymises and serum levels of testosterone and luteinizing hormone. Treatment of BPA
mice with apocynin enhanced the number and motility of sperms of epididymises, but did not affect the serum levels of testosterone and
luteinizing hormone. In addition, exposure to BPA led to enhanced formation of malondialdehyde in testis, and treatment of BPA mice
with apocynin reduced formation of malondialdehyde in testis.Conclusion:Apocynin attenuated BPA-induced injury in sperms of male
adult mice. |
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