| Objective:To study the preparation method of sucrose esters ultrasound contrast agent, and to study the effect of
contrast.Methods:The method of vibration and noise by sucrose esters contrast agent, F68 and Se-5 according to a certain quality that
take configuration microbubbles coated material, the microbubble concentration as an index of preparation optimization, F68 and Se-5 1:
1 quality than weigh, its configuration into emulsion implantation acoustic instrument, acoustic processing with different ultrasonic power
(200 W, 400 W, 600Wand 800 W), different sound and vibration time (30 s, 60 s, 90 s, 120 s, 15 s, 180 s, 210 s, 240 s, 270 s and 300 s).
According to the quality than of 6:1, 5:1,4:1, 3:1, 2:1, 1:1, 2:1, 3:1, 4:1, make SE-5and F68 into the emulsion, the best sound vibration
power and the sound vibration time were selected, and the best solution was selected. The contrast effect of rabbit liver was observed with
the preparation of the micro bubbles under the optimized conditions.Results:The optimum preparation conditions of sucrose esters
contrast agent were: the ratio of 188 (F68 Pluronic) and sucrose ester -5 (SE-5) was 2:1, the vibration instrument power was 600 W, the
duration of sound vibration was 240 s. After injection of contrast agent, the rabbit liver ultrasound contrast images are clear, and the echo
intensity is obviously enhanced.Conclusion:The concentration and diameter of sucrose esters were in accordance with the requirements
of contrast enhanced ultrasound in the preparation process. |
