| 吴佩宏 王霞 杨冬英 殷德荣 柴小萍 李坤.吲哚美辛栓剂对预防ERCP术后高淀粉酶血症及胰腺炎的效果观察[J].现代生物医学进展英文版,2016,16(11):2151-2153. |
| 吲哚美辛栓剂对预防ERCP术后高淀粉酶血症及胰腺炎的效果观察 |
| Observation of Indomethacin Suppository for the Prevention ofHyperamylasemia and Pancreatitis after ERCP Operation |
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| DOI： |
| 中文关键词: 吲哚美辛 ERCP 高淀粉酶血症 胰腺炎 栓剂 |
| 英文关键词: Indomethacin ERCP Hyperamylasemia Pancreatitis Suppository |
| 基金项目:陕西省自然科学基金项目(2014JM4141) |
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| 中文摘要: |
| 目的：探讨吲哚美辛栓剂对预防ERCP 术后高淀粉酶血症及胰腺炎的效果。方法：选取2010 年10 月-2015 年6 月收治入院
的行ERCP 手术的患者300 例，随机分为观察组及对照组各150 例，观察患者ERCP 术后立即应用吲哚美辛栓剂直肠给药，对照
组给予安慰剂栓剂，术后3 h，24 h 检测血清淀粉酶，观察高淀粉酶血症及胰腺炎的发生情况。结果：术前两组血清淀粉酶比较差
异无统计学意义（P>0.05）；术后3 h，24 h两组血清淀粉酶均升高，且观察组高于对照组，差异均具有统计学意义（t=5.794、10.816，
P 均<0.05）。观察组高淀粉酶血症及ERCP术后胰腺炎的发生率明显低于对照组，差异均具有统计学意义（x2=5.927；2.160，P<<0.
05）。结论：直肠给药吲哚美辛栓剂可明显降低ERCP术后血清淀粉酶量，降低高淀粉酶血症及ERCP术后胰腺炎的发生率。 |
| 英文摘要: |
| Objective:To investigate the effect of indomethacin for the prevention of hyperamylasemia and pancreatitis after ERCP
operation.Methods:a total of 300 patients with October 2010 to June 2015 were randomly divided into observation group and control
group for each 150 cases. The patients in observation group were given indometacin suppositories by rectal administration, and the patients
in control group were given placebo suppository. The serumamylase was detected, and the incidence hyperamylasemia and pancreatitis
was observed in 3 h, 24 hours after operation.Results:There was no significant difference in the serum amylase before treatment
between the two groups (P>0.05); After treatment for 3 h and 24 h, the serum amylase was increased in the two groups, and it was higher
in the observation group than that of the control group with statistical significance (t=5.794, 10.816, P<0.05); and the incidence of hyperamylasemia
and pancreatitis after ERCP in the observation group was significantly lower than that of the control group, and the difference
was statistically significant (x2=5.927, 2.160, P<0.05).Conclusion:The rectal indomethacin suppository can significantly decrease the
serumamylase level after ERCP and reduce the incidence of hyperamylasemia and PEP. |
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