| 刘俊杰 张维明 张林芳 吴雪梅 夏成云.氯沙坦对慢性肾功能不全患者血红蛋白、电解质及NO水平的影响[J].现代生物医学进展英文版,2016,16(11):2145-2147. |
| 氯沙坦对慢性肾功能不全患者血红蛋白、电解质及NO水平的影响 |
| Effect of Losartan on the Level of Hemoglobin, Electrolyte and NO inPatients with Chronic Renal Insufficiency |
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| DOI： |
| 中文关键词: 氯沙坦 慢性肾功能不全 血红蛋白 电解质 NO |
| 英文关键词: Losartan Chronic renal insufficiency Hemoglobin Electrolytes NO |
| 基金项目:四川省卫生厅科研基金项目(120331) |
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| 中文摘要: |
| 目的：探讨氯沙坦对慢性肾脏功能不全患者血红蛋白、电解质及NO水平的影响。方法：收集我院收治的慢性肾功能不全患
者140 例，根据用药不同分为对照组和实验组，每组各70 例，对照组给予洛汀新口服治疗，实验组给予氯沙坦口服治疗。分别于
治疗前后检测两组患者血红蛋白（Hb)、红细胞压积(HCT)、血钙、血磷、血钾、内皮素(ET)及一氧化氮（NO）的水平。结果：与治疗前
比较，两组患者治疗后Hb、HCT、血钙及NO水平升高，而血钾、血磷及ET 水平降低，差异具有统计学意义（P<0.05）；与对照组比
较，实验组患者治疗后Hb、HCT、血钙及NO水平较高，而血钾、血磷及ET 水平较低，差异具有统计学意义（P<0.05）。结论：氯沙坦
能够明显升高慢性肾功能不全患者血红蛋白及NO 水平，恢复电解质平衡，改善预后，对临床具有指导意义。 |
| 英文摘要: |
| Objective:To investigate the effect of losartan on the level of hemoglobin, electrolyte and NO in patients with chronic
renal insufficiency.Methods:140 patients with chronic renal insufficiency from our hospital were selected and divided into the control
group and the experiment group with 70 cases in each group. The patients in the control group were treated with lotensin, while the patients
in the experiment group were treated with losartan. Then the Hb, HCT, serum calcium, phosphorus, potassium, ET and NO levels
were detected and compared before and after treatment between two groups.Results:Compared with before treatment, the levels of Hb,
HCT, blood calcium and NO were higher in the two groups, and the serum levels of potassium, phosphorus and ET were lower after the
treatment, and the differences were statistically significant differences (P<0.04); Compared with the control group, the levels of Hb, HCT,
blood calcium and NO were higher in the experiment group, and the serum levels of potassium, phosphorus and ET were lower, and the
differences were statistically significant differences(P<0.04).Conclusion:Losartan can significantly increase the level of hemoglobin and
NO in patients with chronic renal insufficiency, restore the balance of electrolytes and improve prognosis. |
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