| 何光辉 黄民强 伍北寿 许慧良 李梦 李庆云.脉冲震荡肺功能在稳定期COPD治疗中的应用价值[J].现代生物医学进展英文版,2016,16(11):2099-2101. |
| 脉冲震荡肺功能在稳定期COPD治疗中的应用价值 |
| Appling Value of Impulse Oscillometry in Patients with COPDin Stable Stage |
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| DOI： |
| 中文关键词: 慢性阻塞性肺疾病 肺功能 脉冲震荡 呼吸阻抗 |
| 英文关键词: COPD Lung function Impulse oscillometry Respiratory resistance |
| 基金项目:上海市嘉定区科学技术委员会发展基金项目（2014-KW-03）；上海市嘉定区科学技术委员会发展基金项目（063-2012） |
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| 中文摘要: |
| 目的：探讨脉冲震荡肺功能(Impulse oscillometry，IOS)在稳定期COPD 患者中应用价值及其和常规肺功能检测指标的相关
性。方法：62 例重度稳定期COPD 患者，同时选择健康对照组人群40 例纳入研究。经噻托溴铵联合沙美特罗替卡松治疗，将重度
COPD 患者缓解至中度。检测治疗前后常规肺功能指标(FEV1/FVC、FEV1)和IOS 指标(ZRS、Fres、R5、X5、R20)，分析常规肺功能
指标和IOS各指标的相关性。结果：COPD 患者FEV1 和FEV1/FVC 和对照组相比明显降低，差异有统计学意义(P<0.05)，观察组
治疗后FEV1 和FEV1/FVC 明显改善，差异有统计学意义(P<0.05)。观察组ZRS、Fres、R5、R20 各项指标明显高于对照组，差异有
统计学意义(P<0.05)；治疗后ZRS、Fres、R5 明显改善，差异有统计学意义(P<0.05)。FEV1、FEV1/FVC 和ZRS、Fres、R5 呈负相关性
(P<0.05)，和X5 呈正相关性(P<0.05)。结论：脉冲震荡肺功能多项指标和传统肺功能指标有良好的相关性，是一种简便、低配合度、
准确的的肺功能新的检测技术手段。 |
| 英文摘要: |
| Objective:To research the application value of Impulse oscillometry (IOS) in patients with COPD and its correlation
with conventional detecting lung function indexes.Methods:A total of 62 hospitalized patients with COPD in severe stage and 40 health
people as control group were included in this research. These patients were released from severe to moderate stage through Tiotropium
Bromide combined with Salmeterol Fluticasone treatment. The conventional lung function indicators (FEV1/FVC, FEV1) and IOS indexes
(ZRS, Fres, R5, X5, R20) were detected before and after treatment, and the correlation between them were also analyzed.Results:The
FEV1 and FEV1/ FVC of COPD patients were significantly lower than those of the control group, and the difference was statistically significant
(P<0.05). After treatment, the FEV1 and FEV1 / FVC obviously improved in the observation group, with statistically significant
difference (P<0.05). The indicators such as ZRS, Fres, R5 and R20 in observation group were significantly higher than in control group,
and the difference was statistically significant (P<0.05); ZRS, Fres, R5 obviously improved after treatment, and the difference was statistically
significant (P<0.05). FEV1, FEV1/FVC had a negative correlation with ZRS, Fres and R5 (P<0.05), but a positive correlation with
X5 (P<0.05).Conclusion:Many indexes (ZRS, Fres, R5 and X5) of IOS have a good correlation with the traditional lung function indexes.
IOS is a kind of simple but accurate detection technology with low compliance. |
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