| 强毅 袁志△ 段春光 李岩 罗鸣 隋天琪.富血小板血浆联合同种异体骨治疗非感染性骨不连的临床应用[J].现代生物医学进展英文版,2016,16(11):2087-2090. |
| 富血小板血浆联合同种异体骨治疗非感染性骨不连的临床应用 |
| Clinical Application of Platelet-Rich Plasma (PRP) and Artificial BoneComplex in Treatment of Bone Non-union |
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| DOI： |
| 中文关键词: 骨不连 植骨 富血小板血浆 同种异体骨 自体骨 |
| 英文关键词: Bone nonunion Bone grafting Platelet-rich plasma (PRP) Allograft bone Autogenous bone |
| 基金项目:陕西省自然科学基金项目（2015JM8411）；全军医学科技青年培育项目（13QNP130） |
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| 中文摘要: |
| 目的：评价富血小板血浆联合同种异体骨治疗非感染性骨不连的临床疗效。方法：回顾性分析我院创伤骨科2010 年2 月
-2015 年1 月的非感染性骨不连患者，比较同种异体骨加富血小板血浆混合物与自体髂骨植骨治疗非感染性骨不连的疗效。结
果：两组共随访非感染性骨不连患者69 例，全部进行了术中断端植骨，其中富血小板血浆联合同种异体骨植骨组（PRP 组）21 例，
其中愈合19 例，未愈合2 例，临床愈合率90.5 %。自体髂骨植骨组（自体骨组）48 例，愈合44 例，4 例未愈合，临床愈合率91.6%。
PRP 组平均手术持续时间为（108.73± 13.91），自体骨组为（120.54± 13.87）min，两组间有统计学意义（P<0.05）。术后3 月，PRP 组
患者X 线骨痂评价标准平均评分值为（2.54± 0.43）分，自体骨组为（2.62± 0.45）分，两组间差异无统计学意义（P>0.05）。结论：富
血小板血浆混合同种异体骨植骨治疗骨不连较传统自体髂骨植骨可缩短手术时间，避免供骨区并发症，修复效果良好，为骨不连
的治疗提供了一个新的方法。 |
| 英文摘要: |
| Objective:To evaluate the clinical therapeutic effects of platelet rich plasma (PRP) combined allogeneic bone grafting
in the treatment of noninfectious bone nonunion.Methods:Cases of noninfectious bone nonunion were collected from the patients received
by the Department of Traumatic Orthopedics since February 2010 to January 2015. The therapeutic effects between PRP combined
allogeneic bone grafting and autogenous iliac bone grafting were compared by retrospective study.Results:Total of 69 cases were
collected and all of the 69 patients received the treatment of bone grafting in the fracture area. Among the 21 cases in PRP group, 19 cases
were healed, while the other 2 cases remained nonunion. The cure rate was 90.5 %. 44 of the 48 patients received autogenous bone grafting
had complete bone union, besides of 4 cases remaining nonunion. The cure rate was 91.6%. The average duration of surgery was
(108.73± 13.91) min in PRP group and (120.54± 13.87) min in autogenous bone group. The difference had statistical significance (P<0.
05). Reviewed 3 mouth later, the standard average X-ray score of bone callus was (2.54± 0.43) points in PRP group compared with
(2.62± 0.45) points in autogenous bone group. The difference had no statistical significance (P>0.05).Conclusion:PRP combined allogeneic
bone graft shortened the operation time, with the avoidance of the complication in the bone-supply area. There were no significant
differences of the therapeutic effects between two groups, demonstrating the PRP combined allogeneic bone grafting would be a new
method to cure bone nonunion. |
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