| 张林芳 严宏莉 陈欣 邵小东 陈朝辉.血液灌流联合血液透析对慢性肾衰竭患者炎症因子及Hcy、PTH、beta2-MG的影响[J].现代生物医学进展英文版,2016,16(10):1919-1921. |
| 血液灌流联合血液透析对慢性肾衰竭患者炎症因子及Hcy、PTH、beta2-MG的影响 |
| Influence of Hemoperfusion plus Hemodialysis on Inflammatory Factors andHcy, PTH, beta2-MG in Patients with Chronic Renal Failure |
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| DOI： |
| 中文关键词: 血液灌流 血液透析 慢性肾衰竭 炎性因子 |
| 英文关键词: Hemoperfusion Hemodialysis Chronic renal failure Inflammatory factors |
| 基金项目: |
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| 中文摘要: |
| 目的：探索血液灌流（HP）联合血液透析（HD）对慢性肾衰竭（Chronic renal failure, CRF）患者炎症因子及同型半胱氨酸
（Hcy）、甲状腺旁素（PTH）、beta2- 微球蛋白(beta2-MG)的影响。方法：选择自2012 年10 月至2014 年9 月我院收治的98 例CRF 患
者，按照随机数表法将患者分成HD 组和HP 联合HD组（HP+HD组），每组49 例，两组采用相应疗法治疗。由专业的医师对所有
患者治疗前及治疗后1 个月、2 个月、3 个月血清中的炎性因子（IL-1beta、IL-6、IL-8、CRP、TNF-alpha及PCT）及Hcy、PTH、beta2-MG 水平
进行检测并统计分析。结果：与治疗前相比，两组患者治疗后1 个月、2 个月、3 个月血清中的炎症因子及Hcy、PTH、beta2-MG水平
均不同程度下降，而HP+HD组患者在各个时间点血清中的炎症因子及Hcy、PTH、beta2-MG水平均明显低于HD组，且差异均具有
统计学意义（P<0.05）。结论：HP 联合HD较单独使用HD 治疗CRF患者具有更好的疗效，可以明显降低患者体内的炎症因子及
Hcy、PTH、beta2-MG 水平，对于临床上治疗CRF具有重要的指导意义。 |
| 英文摘要: |
| Objective:To explore the influence of hemoperfusion(HP) combined with hemodialysis(HD) on inflammatory factors
and homocysteine(Hcy), para thyroid hormone(PTH),beta2-microglobulin(beta2-MG) in patients with chronic renal failure (CRF).Methods:A
total of 98 patients with CRF, who were admitted to Guang'an People's Hospital from October 2012 to September 2014, were selected
and randomly divided into HD group(n=49) and HP plus HD group(n=49). The two groups were treated with the corresponding therapy.
The serum inflammatory factors (IL-1beta, IL-6, IL-8, CRP, TNF-alphaand PCT) and Hcy, PTH, beta2-MG levels 1 month, 2 months and 3
months before and after treatment in the two groups were detected and statistically analyzed by professional doctors.Results:Compared
with before treatment, the serum inflammatory factors and Hcy, PTH, beta2-MG levels in the two groups decreased 1 month, 2 months and
3 months after treatment, while the above indexes at all time points in HP plus HD group were significantly lower than those in HD
group, the differences were statistically significant (P<0.05).Conclusion:HP combined with HD has a better effect than HD alone in the
treatment of patients with CRF, which can obviously reduce the serum inflammatory factors and Hcy, PTH, beta2-MG levels, it has an
important guiding significance in the clinical CRF treatment. |
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