| 钟阿红 郁春晴 董春林 余进进 吴亦波.miR-124 在消化系统肿瘤研究中的进展[J].现代生物医学进展英文版,2016,16(9):1759-1761. |
| miR-124 在消化系统肿瘤研究中的进展 |
| Advancements of miR-124 on Digestive System Cancers |
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| DOI： |
| 中文关键词: MicroRNA（miRNA） miR-124 功能 肿瘤 消化系统肿瘤 |
| 英文关键词: MicroRNA（miRNA） miR-124 Function Cancer Digestive systemcancer |
| 基金项目:江苏省自然科学基金项目（BK20140170）；无锡市科技计划项目（CSE31N1316） |
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| 中文摘要: |
| 消化系统肿瘤严重危害人类健康，是导致死亡的主要原因，其一直是科学研究的一个重点，也是难点。MicroRNA(miRNA)是
一类广泛存在于生物体内的内源性、非编码、单链小分子RNA，参与调控生物体的几乎所有生命活动，包括多种生理和病理活动。
目前研究认为，miRNAs参与肿瘤的发生和进展。miR-124是miRNAs家族的一员，是一个相当保守的miRNA，在多种肿瘤包括消
化系统肿瘤的细胞或组织中均表达下调，扮演着类似抑癌基因的角色，在该类肿瘤的发生、发展以及预后中发挥重要作用。本文
就miR-124 在消化系统肿瘤研究中的进展作一综述。 |
| 英文摘要: |
| Cancers of the digestive system constitute a serious public health problem and are the leading cause of death worldwide.
It has always been one of the difficulty and emphases of research. MicroRNAs (miRNAs) are a family of small, endogenous,
non-coding, single-stranded RNA molecules estimated to negatively modulate gene expression in organisms, which have important roles
in regulating diverse physiological and pathological processes. MiR-124, highly conserved, is down-expressed in many kinds of human
cancers especially digestive system cancers. By recent research, miR-124, as the tumor suppressor gene, is closely related to the occurrence,
development and prognosis of these cancers. This article reviews the present research progresses of miR-124 in digestive system
cancers. |
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