| 张月辉 魏淑琴 魏陵博 张崇荣 吴暖.老年高血压前期患者糖耐量降低对内皮功能及颈动脉粥样硬化的影响[J].现代生物医学进展英文版,2016,16(9):1721-1723. |
| 老年高血压前期患者糖耐量降低对内皮功能及颈动脉粥样硬化的影响 |
| Elderly Patients with Prehypertension: Influence of Impaired GlucoseTolerance on Endothelial Function and Carotid Atherosclerosis |
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| DOI： |
| 中文关键词: 高血压 糖耐量降低 内皮功能 动脉粥样硬化 |
| 英文关键词: Hypertension Impaired glucose tolerance Endothelial function Atherosclerosis |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨老年人高血压前期糖耐量降低（IGT）对血管内皮功能和颈动脉粥样硬化的影响。方法：选择2013 年1 月至2014
年1 月在我院门诊、住院和体检中心纳入的60 岁以上志愿者240 例，依据血压、血糖水平将志愿者分为四组，单纯高血压前期
（PH）组，单纯IGT（IGT）组，高血压前期并发IGT（PH&IGT）组，正常对照（NC）组，每组均为60 例。检测颈动脉内中膜厚度（IMT）
和内皮依赖性血管舒张功能（FMD）并进行相关性分析。结果：与NC组相比，IMT 在PH组、IGT组和PH&IGT组显著升高[(0.74±
0.09)mm、(0.76± 0.12)mm、(0.96± 0.14）mmvs（0.57± 0.08）mm，均P<0.05]，且PH&IGT组相比于PH组和IGT组进一步升高（P<0.05）；与
NC 组相比，FMD 在PH组、IGT 组和PH&IGT 组显著降低[(8.77± 2.56) %、(8.59± 2.37) %、(5.78± 2.11）%vs（12.48± 2.78）%，均
P<0.05]，且PH&IGT 组相比于PH组和IGT 组进一步下降（P<0.05）。直线相关分析显示，IMT 与FMD 呈显著负相关，相关性检验
有统计学意义（r=-0.843，P<0.01）。结论：高血压前期患者血管内皮功能受损，在高血压前期基础上的IGT 将会加剧血管内皮功能
障碍和动脉粥样硬化。 |
| 英文摘要: |
| Objective:To study the influence of impaired glucose tolerance(IGT) on endothelial function and carotid atherosclerosis
in elderly patients with prehypertension.Methods:A total of 240 volunteers (age≥ 60 years old) in outpatient, inpatient and medical
center of Qingdao Haici Medical Group from January 2013 to January 2014 were selected and divided into normal control group(NC
group, n=60), prehypertension group(PH group, n=60), IGT group(n=60), prehypertension and IGT group(PH&IGT group, n=60) according
to the blood pressure and blood glucose level. The intima-media thickness (IMT) and flow mediated diameter (FMD) in the four
groups were detected, and their correlation was analyzed.Results:Compared with NC group, IMT in PH, IGT and PH&IGT groups significantly
increased [(0.74± 0.09)mm, (0.76± 0.12)mm and (0.96± 0.14)mm vs (0.57± 0.08)mm, all P<0.05]; IMT in PH&IGT group
significantly increased compared with PH and IGT group(P<0.05); FMD in PH, IGT and PH&IGT groups significantly decreased[(8.77±
2.56)%, (8.59± 2.37)%, and (5.78± 2.11)% vs (12.48± 2.78)%, all P<0.05], FMD in PH&IGT group significantly decreased compared
with PH and IGT group (P<0.05). Linear correlation analysis showed that FMD was negatively correlated with IMT (r=-0.843, P<0.01).Conclusion:Vascular endothelial function is obviously impaired in elderly patients with prehypertension, on the basis of which, IGT will
exacerbate the endothelial dysfunction and atherosclerosis. |
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