| 施凌云 何华平 姚文君 柴冬雪 郭志勇.血液透析联合血液透析滤过对患者营养及微炎症指标的影响[J].现代生物医学进展英文版,2016,16(9):1701-1703. |
| 血液透析联合血液透析滤过对患者营养及微炎症指标的影响 |
| Influence of Hemodialysis Plus Hemodiafiltration on Nutrition Status andMicroinflammation of Patients Undergoing Maintenance Hemodialysis |
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| DOI： |
| 中文关键词: 血液透析 血液透析滤过 营养状态 微炎症 |
| 英文关键词: Hemodialysis Hemodiafiltration Nutrition status Microinflammation |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨血液透析(HD)联合血液透析滤过(HDF)对维持性血液透析(MHD)患者营养及微炎症指标的影响。方法：选择
2005 年12 月到2014年12 月在我院接受治疗的140 例MHD患者，随机分为HD组（n=70）和HD+HDF 组（n=70）。比较两组患
者治疗前后营养不良- 炎症评分(MIS)、C 反应蛋白(CRP)、白细胞介素6(IL-6)、白蛋白(ALB)、前白蛋白(PA)、血红蛋白(Hb)、握力
(HS)、肱三头肌皮褶厚度(TSF)的变化。结果：治疗后，HD+HDF 组患者MIS 明显降低，ALB、PA、Hb、HS、TSF 明显升高（均P<0.
05），且各指标改善程度均优于HD组（均P<0.05）；治疗后，HD+HDF 组患者相比于治疗前和HD 组治疗后，CRP、IL-6 明显降低
（均P<0.05）。结论：HD联合HDF较单纯HD能更好的改善患者营养状态，减轻微炎症反应。 |
| 英文摘要: |
| Objective:To investigate the influence of hemodialysis(HD) combined with hemodiafiltration(HDF) on nutrition status
and microinflammation in maintenance hemodialysis(MHD)patients.Methods:A total of 140 patients, who underwent MHD in Changhai
Affiliated Hospital of Second Military Medical University from December 2005 to December 2014, were selected and randomly divided
into HD group(n=70) and HD+HDF group(n=70). Then the malnutrition inflammation score(MIS),C-reactive protein(CRP), interleukin-6
(IL-6), serum albumin(ALB), prealbumin(PA), hemoglobin(Hb), handgrip strength(HS), brachial, three triceps skinfold thickness(TSF)
before and after treatment were compared in the two groups.Results:After treatment, in HD+HDF group MIS was significantly reduced
and ALB, PA, Hb, HS, TSF significantly increased, and the improvement in HD+HDF group was significantly better than HD group(P<0.
05); CRP and IL-6 were significantly lower than before treatment and HD group after treatment (P<0.05).Conclusion:Hemodialysis plus
hemodiafiltration can improve the nutrition status and reduce microinflammation, better than hemodialysis alone for MHD patients. |
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