| 李明莉 史君英 王玲 黄涛 杨冉 王庆国 侯善荣.糖尿病患者的MPV、脂联素水平与冠心病的关系[J].现代生物医学进展英文版,2016,16(9):1676-1679. |
| 糖尿病患者的MPV、脂联素水平与冠心病的关系 |
| The Relationship between Mean platelet volume(MPV), Adiponectin andCoronary Heart Disease in the Diabetic |
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| DOI： |
| 中文关键词: 糖尿病 冠心病 脂联素 血小板平均体积 |
| 英文关键词: Diabetes mellitus Coronary heart disease Adiponectin Mean platelet volume |
| 基金项目:国家科技支撑计划项目（2015BAI06B05） |
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| 中文摘要: |
| 目的：研究糖尿病(Diabetes Mellitus，DM)患者血小板体积（mean platelet volume，MPV）和血清脂联素水平与冠心病的关系。
方法：选取研究对象共150 例分为三组，其中101 名糖尿病患者根据冠脉造影结果分为：A 组（糖尿病合并冠心病组）共72人，B
组（糖尿病非冠心病组）共29 人。对照组为排除糖尿病且冠脉造影正常者共49 人。入院次日检测空腹血常规（含MPV），应用
ELISA 法检测各组血清脂联素水平。应用Gensini评分系统评估冠状动脉的狭窄程度。结果：A 组和B 组的脂联素水平均低于对
照组(P<0.05)，且A组脂联素水平低于B组(P<0.05)。A 组与B 组MPV 水平均高于对照组(P<0.05)，且A 组MPV 水平高于B 组
(P<0.05)。相关性分析显示Gensini评分与脂联素水平负相关（r=-0.59，P<0.001），Gensini评分与MPV 正相关（r=0.56，P<0.001）。结
论：脂联素、MPV与糖尿病合并冠心病的发生显著相关，而脂联素可能通过拮抗糖尿病患者血小板活性程度，延缓心血管并发症
的发生。 |
| 英文摘要: |
| Objective:To investigate the relationship between mean platelet volume, adiponectin and coronary heart disease in the
diabetic.Methods:One hundred and fifty subjects were selected and divided into three groups. Among them, One hundred and one diabetic
patients were divided into two groups according to the results of the coronary angiography: 72 patients coexistent coronary artery
disease were selected as group A, 29 patients without coronary artery disease were selected as group B. Forty-nine subjects without diabetes
with normal coronary angiographies, were taken as the control group. Blood routine (MPV) were measured at the second day after
admitted and the serum adiponectin levels were detected by Elisa. To evaluate the extension of CHD, Gensini scoring system was used.Results:The serumlevels of adiponectin were significantly lower in the group A and the group B than that of control group (P<0.05). The
serum levels of adiponectin were lower in group A than that of groupB (P<0.05). The MPV were significantly higher in group A and
group B than that of control group (P<0.05). The MPV were higher in groupA than that of group B (P<0.05). The serum adiponectin levels
was associated with gensini score (r=-0.59, P<0.001). The MPV was associated with gensini score (r=0.56, P<0.001).Conclusion:Adiponectin and MPV are involved in the pathogenesis of diabetic vascular complications. Adiponectin may inhibit platelet activity in
DMpatients, to delay the development of coronary artery disease. |
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