| Objective:To investigate the neuromuscular blockade, safety and requirements of mivacurium for general anesthesia,
while sevoflurane and propofol were used.Methods:Forty patients scheduled for gynecological surgery were randomly divided into
sevoflurane group (group S, n=20) and propofol group (group P, n=20). The mivacurium was injected singly during the induction period,
and resume to inject at the beginning of muscle relaxation recovery, and stop to pump about 20 min before the end of surgery. The onset
time, no response period, recovery time of TOFr (25 %, 50 %, 75 %, 90 %), recovery index, average infusion rate, and average additional
times were recorded.Results:There are two cases and one case with mild skin flushing in group S and group P respectively. One patient
had mild cough without obvious abnormalities of blood pressure and heart rate in group P. The intubation conditions were all satisfied in
both groups. The onset time of induction, no response period and recovery index have no differences in two groups (P>0.05). After stop
pumping mivacurium, the recovery time of 25%, 50%, 75%, 90%are significantly longer in group S than groupP (P<0.05). The average
infusion rate and additional times of mivacuriumwere lower in group S than group P during the maintaining period (P<0.05).Conclusion:The neuromuscular blockade, rapid recovery and security should be affirmed when mivacurium was used for general anesthesia. Sevoflurane
compared with propofol, the requirement of mivacuriumcan be reduced fromabout 20%to 30 %, the specific effects of propofol on
mivacuriumdose need to be studied further. |
