| 孙晓琴 易山 牛香莲 米锴 孙茂盛.miRNA参与肿瘤基因表达调控研究进展[J].现代生物医学进展英文版,2016,16(8):1551-1554. |
| miRNA参与肿瘤基因表达调控研究进展 |
| Advances in the Research of Correlation between miRNAand gene Regulation in Tumor |
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| DOI： |
| 中文关键词: iRNA 肿瘤 基因表达调控 |
| 英文关键词: miRNA Cancer Gene expression regulation |
| 基金项目:国家863 项目(2012AA02A404)；重大新药创制专项（2014ZX09102041004）；云南省应用基础研究计划面上项目(2009CD142) |
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| 中文摘要: |
| 调查表明，我国城乡居民恶性肿瘤死亡率属于世界较高水平，而且呈持续的增长趋势。近年来的研究发现在肿瘤的发生与
发展过程中涉及到多种因素，其中miRNA 可能扮演了重要的作用。miRNA 是一种长度约为22 nt 的非编码短序列RNA，通过介
导特异性的基因沉默导致靶mRNA降解，促使相应蛋白质的转译受阻而失去原有编码蛋白质的功能。miRNA在细胞分裂周期中
影响着基因的表达调控，在此过程中基因表达的失控就可能导致疾病的发生。而肿瘤的发生是以细胞恶变为基础，细胞恶变则是
与细胞周期调控因素失衡相关，由此提示了一些miRNA可能参与了肿瘤的发生、发展过程并在其中发挥了重要作用。随着研究
的深入，miRNA逐渐成为肿瘤诊治的新研究方向。本文主要讨论miRNA 在肿瘤基因表达调控方面的研究进展。 |
| 英文摘要: |
| The results of the survey demonstrate that the malignant tumor mortality of urban and rural residents belongs to the
higher level and the continued growth trend in our country. In recent years, researches has found that miRNA plays an important role in
the process of the occurrence and development of tumor. MiRNA is a kind of small non-coding RNA with about 22 nucleotides, which
participates in regulating gene expression at the post-transcriptional leve1.Post-transcriptional silencing of target genes by miRNA occurs
either by targeting specific cleavage of mRNA or by targeting specific protein synthesis. MiRNA can regulate the gene expression in cell
cycles, which dysfunction often lead to human disease. The occurrence of tumor is based on cell malignant transformation, which is
related to the regulating factor of cell cycle unbalanced. This suggesting that some miRNAs may participate in the occurrence and
development process of tumor and play a key role.With the deepening of the research, miRNA will become the new direction for
diagnosis and treatment of tumor. In this review, I will discuss the progress in the study on miRNA in gene regulation of cancer. |
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