| 武文峰 江龙 王春梅 聂绍平 王绿娅.早发冠心病患者的危险因素及冠脉病变特点研究[J].现代生物医学进展英文版,2016,16(8):1537-1540. |
| 早发冠心病患者的危险因素及冠脉病变特点研究 |
| Risk Factors and Coronary Features of Patients with Premature CoronaryArtery Disease |
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| DOI： |
| 中文关键词: 早发冠心病 危险因素 冠脉病变特点 |
| 英文关键词: Premature coronary artery disease Risk factors Coronary artery lesions |
| 基金项目:国家自然科学基金项目（81471098，81170810） |
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| 中文摘要: |
| 目的：探讨早发冠心病(PCAD)患者的危险因素及冠脉病变特点。方法：收集2014 年8 月至2015 年2月北京安贞医院急诊
科行冠状动脉造影的1000 例患者为研究对象，根据冠状动脉造影结果和临床资料分为早发冠心病(PCAD) 组(男<55 岁，女<65
岁，n=340)、晚发冠心病组(n=300)和对照组(非冠心病者，n=360)。对三组患者的临床资料进行统计学分析，采用logistic回归分析
PCAD 患者的危险因素，并比较PCAD 组与晚发冠心病组的冠状动脉病变特点。结果：Logistic 回归分析结果提示：吸烟、早发冠
心病家族史、高血压病及2 型糖尿病是PCAD的独立危险因素(P<0.001)。PCAD 组单支病变比例显著高于晚发冠心病组(P<0.
05)；回旋支、右冠状动脉病变比例低于晚发冠心病组(P<0.05)。结论：吸烟、早发冠心病家族史、高血压病及2 型糖尿病是PCAD
的独立危险因素。早发冠心病患者冠脉病变主要累及前降支，单支病变多于晚发冠心病患者。 |
| 英文摘要: |
| Objective:To evaluate the risk factor and features of coronary artery lesions in patients with premature coronary artery
disease (PCAD).Methods:The baseline clinical and coronary angiographic data of 1000 patients undergoing coronary angiography
(CAG) were collected and analyzed. All patients were divided into PCAD group (n = 340, female＜65 years, male＜55 years), late-onset
CAD group (n = 300) and non-CAD group (n = 360). Using logistic regression analysis of risk factors in patients with PCAD,
Characteristics of coronary artery lesions were compared in PCAD group and late-onset CAD group.Results:In the control group as a
reference to logistic regression analysis, the result of hypertension, type 2 diabetes, smoking and family history of premature coronary
artery disease was an independent risk factor for premature coronary artery disease (P<0.001). Single branch lesion proportion of
early-onset group was significantly higher than that of the late group; and the proportion of left circumflex artery, right coronary artery
lesion was significantly lower than that of the late group.Conclusion:Hypertension, type 2 diabetes, smoking and family history of
PCAD are independent risk factors of PCAD. PCAD patients suffered more single vessel coronary artery lesions than late-onset CAD
patients and mainly were anterior descending branch lesions. |
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